Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs
Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34...
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| Veröffentlicht in: | Heart and vessels 2021-01, Vol.36 (1), p.105-114 |
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| creator | Tabata, Tokiko Yamashita, Tomoya Hosomi, Koji Park, Jonguk Hayashi, Tomohiro Yoshida, Naofumi Saito, Yoshihiro Fukuzawa, Koji Konishi, Kana Murakami, Haruka Kawashima, Hitoshi Mizuguchi, Kenji Miyachi, Motohiko Kunisawa, Jun Hirata, Ken-ichi |
| description | Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level,
Enterobacter
was depleted, while
Parabacteroides
,
Lachnoclostridium
,
Streptococcus,
and
Alistipes
were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits. |
| doi_str_mv | 10.1007/s00380-020-01669-y |
| format | Article |
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Enterobacter
was depleted, while
Parabacteroides
,
Lachnoclostridium
,
Streptococcus,
and
Alistipes
were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-020-01669-y</identifier><identifier>PMID: 32683492</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Biomedical Engineering and Bioengineering ; Cardiac arrhythmia ; Cardiac Surgery ; Cardiology ; Composition ; Congestive heart failure ; Diet ; Dysbacteriosis ; Fatty acids ; Fibrillation ; Gene sequencing ; Intestinal microflora ; Medicine ; Medicine & Public Health ; Metabolites ; Microbiota ; Microorganisms ; Original ; Original Article ; Polyunsaturated fatty acids ; Quality of life ; rRNA 16S ; Vascular Surgery</subject><ispartof>Heart and vessels, 2021-01, Vol.36 (1), p.105-114</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c608t-2846dc14be55ab5e01409d35eab34b9f2d4089a1df0694916d05bb7965a7b00c3</citedby><cites>FETCH-LOGICAL-c608t-2846dc14be55ab5e01409d35eab34b9f2d4089a1df0694916d05bb7965a7b00c3</cites><orcidid>0000-0003-0267-3842</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00380-020-01669-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00380-020-01669-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32683492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tabata, Tokiko</creatorcontrib><creatorcontrib>Yamashita, Tomoya</creatorcontrib><creatorcontrib>Hosomi, Koji</creatorcontrib><creatorcontrib>Park, Jonguk</creatorcontrib><creatorcontrib>Hayashi, Tomohiro</creatorcontrib><creatorcontrib>Yoshida, Naofumi</creatorcontrib><creatorcontrib>Saito, Yoshihiro</creatorcontrib><creatorcontrib>Fukuzawa, Koji</creatorcontrib><creatorcontrib>Konishi, Kana</creatorcontrib><creatorcontrib>Murakami, Haruka</creatorcontrib><creatorcontrib>Kawashima, Hitoshi</creatorcontrib><creatorcontrib>Mizuguchi, Kenji</creatorcontrib><creatorcontrib>Miyachi, Motohiko</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Hirata, Ken-ichi</creatorcontrib><title>Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level,
Enterobacter
was depleted, while
Parabacteroides
,
Lachnoclostridium
,
Streptococcus,
and
Alistipes
were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.</description><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Composition</subject><subject>Congestive heart failure</subject><subject>Diet</subject><subject>Dysbacteriosis</subject><subject>Fatty acids</subject><subject>Fibrillation</subject><subject>Gene sequencing</subject><subject>Intestinal microflora</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Original</subject><subject>Original Article</subject><subject>Polyunsaturated fatty acids</subject><subject>Quality of life</subject><subject>rRNA 16S</subject><subject>Vascular Surgery</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><recordid>eNp9kT9vFDEQxS0EIkfgC1AgS9QL4_82BRKKICBFooGCyrLX3oujvfVhe4Pu2-PjQoCGYjTF_ObN0zyEnhN4RQDU6wrANAxAexEpzXB4gDZEEjFQodhDtAFDYNCMqjP0pNYbACIMMY_RGaNSM27oBn27XBvepbFkn9yMx7zb55paygtOC967luLSKv6R2jV2rRyZKfmS5tkdoTc4TlMcO5EnHFJs2C0Bh7Ju61P0aHJzjc_u-jn6-uH9l4uPw9Xny08X766GUYJuA9VchpFwH4VwXkQgHExgIjrPuDcTDRy0cSRMIA03RAYQ3isjhVMeYGTn6O1Jd7_6XQxj91vcbPcl7Vw52OyS_XeypGu7zbdWKa2Bki7w8k6g5O9rrM3e5LUs3bOlXAmtKJe0U_RE9VfVWuJ0f4GAPcZhT3HYHof9FYc99KUXf3u7X_n9_w6wE1D7aNnG8uf2f2R_AnnIl9c</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Tabata, Tokiko</creator><creator>Yamashita, Tomoya</creator><creator>Hosomi, Koji</creator><creator>Park, Jonguk</creator><creator>Hayashi, Tomohiro</creator><creator>Yoshida, Naofumi</creator><creator>Saito, Yoshihiro</creator><creator>Fukuzawa, Koji</creator><creator>Konishi, Kana</creator><creator>Murakami, Haruka</creator><creator>Kawashima, Hitoshi</creator><creator>Mizuguchi, Kenji</creator><creator>Miyachi, Motohiko</creator><creator>Kunisawa, Jun</creator><creator>Hirata, Ken-ichi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0267-3842</orcidid></search><sort><creationdate>20210101</creationdate><title>Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs</title><author>Tabata, Tokiko ; Yamashita, Tomoya ; Hosomi, Koji ; Park, Jonguk ; Hayashi, Tomohiro ; Yoshida, Naofumi ; Saito, Yoshihiro ; Fukuzawa, Koji ; Konishi, Kana ; Murakami, Haruka ; Kawashima, Hitoshi ; Mizuguchi, Kenji ; Miyachi, Motohiko ; Kunisawa, Jun ; Hirata, Ken-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c608t-2846dc14be55ab5e01409d35eab34b9f2d4089a1df0694916d05bb7965a7b00c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Composition</topic><topic>Congestive heart failure</topic><topic>Diet</topic><topic>Dysbacteriosis</topic><topic>Fatty acids</topic><topic>Fibrillation</topic><topic>Gene sequencing</topic><topic>Intestinal microflora</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Original</topic><topic>Original Article</topic><topic>Polyunsaturated fatty acids</topic><topic>Quality of life</topic><topic>rRNA 16S</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tabata, Tokiko</creatorcontrib><creatorcontrib>Yamashita, Tomoya</creatorcontrib><creatorcontrib>Hosomi, Koji</creatorcontrib><creatorcontrib>Park, Jonguk</creatorcontrib><creatorcontrib>Hayashi, Tomohiro</creatorcontrib><creatorcontrib>Yoshida, Naofumi</creatorcontrib><creatorcontrib>Saito, Yoshihiro</creatorcontrib><creatorcontrib>Fukuzawa, Koji</creatorcontrib><creatorcontrib>Konishi, Kana</creatorcontrib><creatorcontrib>Murakami, Haruka</creatorcontrib><creatorcontrib>Kawashima, Hitoshi</creatorcontrib><creatorcontrib>Mizuguchi, Kenji</creatorcontrib><creatorcontrib>Miyachi, Motohiko</creatorcontrib><creatorcontrib>Kunisawa, Jun</creatorcontrib><creatorcontrib>Hirata, Ken-ichi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tabata, Tokiko</au><au>Yamashita, Tomoya</au><au>Hosomi, Koji</au><au>Park, Jonguk</au><au>Hayashi, Tomohiro</au><au>Yoshida, Naofumi</au><au>Saito, Yoshihiro</au><au>Fukuzawa, Koji</au><au>Konishi, Kana</au><au>Murakami, Haruka</au><au>Kawashima, Hitoshi</au><au>Mizuguchi, Kenji</au><au>Miyachi, Motohiko</au><au>Kunisawa, Jun</au><au>Hirata, Ken-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>36</volume><issue>1</issue><spage>105</spage><epage>114</epage><pages>105-114</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>Atrial fibrillation (AF) reduces the quality of life by triggering stroke and heart failure. The association between AF onset and gut metabolites suggests a causal relationship between AF and gut microbiota dysbiosis; however, the relationship remains poorly understood. We prospectively enrolled 34 hospitalized patients with AF and 66 age-, sex-, and comorbidity-matched control subjects without a history of AF. Gut microbial compositions were evaluated by amplicon sequencing targeting the 16S ribosomal RNA gene. We assessed differences in dietary habits by using a brief-type self-administered diet history questionnaire (BDHQ). Gut microbial richness was lower in AF patients, although the diversity of gut microbiota did not differ between the two groups. At the genus level,
Enterobacter
was depleted, while
Parabacteroides
,
Lachnoclostridium
,
Streptococcus,
and
Alistipes
were enriched in AF patients compared to control subjects. The BDHQ revealed that the intake of n-3 polyunsaturated fatty acids and eicosadienoic acid was higher in AF patients. Our results suggested that AF patients had altered gut microbial composition in connection with dietary habits.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>32683492</pmid><doi>10.1007/s00380-020-01669-y</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0267-3842</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical Engineering and Bioengineering Cardiac arrhythmia Cardiac Surgery Cardiology Composition Congestive heart failure Diet Dysbacteriosis Fatty acids Fibrillation Gene sequencing Intestinal microflora Medicine Medicine & Public Health Metabolites Microbiota Microorganisms Original Original Article Polyunsaturated fatty acids Quality of life rRNA 16S Vascular Surgery |
| title | Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs |
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