Gandouling Tablets Inhibit Excessive Mitophagy in Toxic Milk (TX) Model Mouse of Wilson Disease via Pink1/Parkin Pathway

Objective. Gandouling (GDL) tablet is a Chinese patent medicine approved by the National Medical Product Administration, which is used to treat Wilson disease (WD) in China. In this study, we aimed to investigate the effects of GDL on mitophagy in the hippocampus in the toxic milk (TX) mouse model o...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-11
Hauptverfasser:	Yu, Gu-Ran, Xie, Dao-Jun, Chen, Huai-Zhen, Jin, Shan, Cui, Shen-Wei, Li, Liang-Yong, Tang, Lu-Lu, Zhang, Jing, Yang, Wen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Animals Apoptosis Aspartate transaminase Autophagy Bilirubin Chinese medicine Disease Drug dosages Enzyme-linked immunosorbent assay Ethics Fluorescence microscopy Gene expression Mitochondria Mitophagy Mutation Neuroprotection Oxidative stress Parkin protein Polymerase chain reaction PTEN-induced putative kinase Reverse transcription Transaminase Transmission electron microscopy Western blotting Wilson's disease
Online-Zugang:	Volltext
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