Rad18 mediates specific mutational signatures and shapes the genomic landscape of carcinogen-induced tumors in vivo

The E3 ubiquitin ligase Rad18 promotes a damage-tolerant and error-prone mode of DNA replication termed trans-lesion synthesis that is pathologically activated in cancer. However, the impact of vertebrate on cancer genomes is not known. To determine how Rad18 affects mutagenesis , we have developed...

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Veröffentlicht in:	NAR cancer 2021-03, Vol.3 (1), p.zcaa037
Hauptverfasser:	Lou, Jitong, Yang, Yang, Gu, Qisheng, Price, Brandon A, Qiu, Yuheng, Fedoriw, Yuri, Desai, Siddhi, Mose, Lisle E, Chen, Brian, Tateishi, Satoshi, Parker, Joel S, Vaziri, Cyrus, Wu, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Genomics
Online-Zugang:	Volltext
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