Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. Adverse effects of the vaccine were mild, transient local...
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| Veröffentlicht in: | The New England journal of medicine 2021-02, Vol.384 (5), p.403-416 |
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| container_title | The New England journal of medicine |
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| creator | Baden, Lindsey R El Sahly, Hana M Essink, Brandon Kotloff, Karen Frey, Sharon Novak, Rick Diemert, David Spector, Stephen A Rouphael, Nadine Creech, C. Buddy McGettigan, John Khetan, Shishir Segall, Nathan Solis, Joel Brosz, Adam Fierro, Carlos Schwartz, Howard Neuzil, Kathleen Corey, Larry Gilbert, Peter Janes, Holly Follmann, Dean Marovich, Mary Mascola, John Polakowski, Laura Ledgerwood, Julie Graham, Barney S Bennett, Hamilton Pajon, Rolando Knightly, Conor Leav, Brett Deng, Weiping Zhou, Honghong Han, Shu Ivarsson, Melanie Miller, Jacqueline Zaks, Tal |
| description | Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. Adverse effects of the vaccine were mild, transient local reactions, and the incidence of systemic effects such as fever, headache, and fatigue was low. |
| doi_str_mv | 10.1056/NEJMoa2035389 |
| format | Article |
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Buddy ; McGettigan, John ; Khetan, Shishir ; Segall, Nathan ; Solis, Joel ; Brosz, Adam ; Fierro, Carlos ; Schwartz, Howard ; Neuzil, Kathleen ; Corey, Larry ; Gilbert, Peter ; Janes, Holly ; Follmann, Dean ; Marovich, Mary ; Mascola, John ; Polakowski, Laura ; Ledgerwood, Julie ; Graham, Barney S ; Bennett, Hamilton ; Pajon, Rolando ; Knightly, Conor ; Leav, Brett ; Deng, Weiping ; Zhou, Honghong ; Han, Shu ; Ivarsson, Melanie ; Miller, Jacqueline ; Zaks, Tal ; COVE Study Group</creatorcontrib><description>Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. 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All rights reserved.</rights><rights>Copyright © 2020 Massachusetts Medical Society.</rights><rights>Copyright © 2020 Massachusetts Medical Society. All rights reserved. 2020 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c627t-c38af8980440698f7abc4e8e744890d4f74c00c0a3b623c5a362a5d2800a8d0a3</citedby><cites>FETCH-LOGICAL-c627t-c38af8980440698f7abc4e8e744890d4f74c00c0a3b623c5a362a5d2800a8d0a3</cites><orcidid>0000-0003-0489-0074 ; 0000-0002-2179-2436</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2035389$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2035389$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33378609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baden, Lindsey R</creatorcontrib><creatorcontrib>El Sahly, Hana M</creatorcontrib><creatorcontrib>Essink, Brandon</creatorcontrib><creatorcontrib>Kotloff, Karen</creatorcontrib><creatorcontrib>Frey, Sharon</creatorcontrib><creatorcontrib>Novak, Rick</creatorcontrib><creatorcontrib>Diemert, David</creatorcontrib><creatorcontrib>Spector, Stephen A</creatorcontrib><creatorcontrib>Rouphael, Nadine</creatorcontrib><creatorcontrib>Creech, C. Buddy</creatorcontrib><creatorcontrib>McGettigan, John</creatorcontrib><creatorcontrib>Khetan, Shishir</creatorcontrib><creatorcontrib>Segall, Nathan</creatorcontrib><creatorcontrib>Solis, Joel</creatorcontrib><creatorcontrib>Brosz, Adam</creatorcontrib><creatorcontrib>Fierro, Carlos</creatorcontrib><creatorcontrib>Schwartz, Howard</creatorcontrib><creatorcontrib>Neuzil, Kathleen</creatorcontrib><creatorcontrib>Corey, Larry</creatorcontrib><creatorcontrib>Gilbert, Peter</creatorcontrib><creatorcontrib>Janes, Holly</creatorcontrib><creatorcontrib>Follmann, Dean</creatorcontrib><creatorcontrib>Marovich, Mary</creatorcontrib><creatorcontrib>Mascola, John</creatorcontrib><creatorcontrib>Polakowski, Laura</creatorcontrib><creatorcontrib>Ledgerwood, Julie</creatorcontrib><creatorcontrib>Graham, Barney S</creatorcontrib><creatorcontrib>Bennett, Hamilton</creatorcontrib><creatorcontrib>Pajon, Rolando</creatorcontrib><creatorcontrib>Knightly, Conor</creatorcontrib><creatorcontrib>Leav, Brett</creatorcontrib><creatorcontrib>Deng, Weiping</creatorcontrib><creatorcontrib>Zhou, Honghong</creatorcontrib><creatorcontrib>Han, Shu</creatorcontrib><creatorcontrib>Ivarsson, Melanie</creatorcontrib><creatorcontrib>Miller, Jacqueline</creatorcontrib><creatorcontrib>Zaks, Tal</creatorcontrib><creatorcontrib>COVE Study Group</creatorcontrib><title>Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Two injections of mRNA-1273, a lipid nanoparticle–encapsulated mRNA-based vaccine produced in collaboration with the NIAID that encodes the SARS-CoV-2 spike protein, conferred protection against Covid-19 illness in 94% of vaccinated patients. 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| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-02, Vol.384 (5), p.403-416 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7787219 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | 2019-nCoV Vaccine mRNA-1273 Adolescent Adult Adverse events Age Aged Allergies Cardiovascular disease Coronaviridae Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - adverse effects COVID-19 Vaccines - immunology Disease prevention Disease transmission Drug dosages Drug stores Enrollments Female Humans Incidence Infections Infectious diseases Male Middle Aged mRNA Nanoparticles Original Patient Acuity Placebos R&D Research & development SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Single-Blind Method Spike Glycoprotein, Coronavirus Spike protein Treatment Outcome Vaccine efficacy Vaccines Young Adult |
| title | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine |
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