Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells

Drug repurposing is a cost-effective means of targeting new therapies for cancer. We have examined the effects of the repurposed drugs, bezafibrate, medroxyprogesterone acetate and valproic acid on human osteosarcoma cells, i.e., SAOS2 and MG63 compared with their normal cell counterparts, i.e. mese...

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Veröffentlicht in:	Bioscience reports 2021-01, Vol.41 (1)
Hauptverfasser:	Sheard, Jonathan J, Southam, Andrew D, MacKay, Hannah L, Ellington, Max A, Snow, Martyn D, Khanim, Farhat L, Bunce, Christopher M, Johnson, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Apoptosis Bezafibrate Bezafibrate - administration & dosage Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - enzymology Bone Neoplasms - pathology Cancer Cell culture Cell Cycle, Growth & Proliferation Cell death Cell division Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - drug effects Cytotoxicity Desaturase Down-Regulation Drug Repositioning Drug Therapy, Combination Drugs Fatty Acid Synthases - metabolism Fatty-acid synthase Humans Immunoblotting Leukemia Lipid metabolism Lipids Lymphoma Medical prognosis Medroxyprogesterone acetate Medroxyprogesterone Acetate - administration & dosage Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - enzymology Osteosarcoma - pathology Osteosarcoma cells Pharmacology & Toxicology Phenotypes Sarcoma Software Stearoyl-CoA Desaturase - metabolism Stem Cells Stromal cells Survival Toxicity Up-Regulation Valproic acid Valproic Acid - administration & dosage
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