GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson's disease

Wilson's disease (WD) is an autosomal recessive disease caused by mutation of the ATPase copper transporting β (ATP7B) gene, resulting in abnormal copper metabolism. We aimed to investigate the protective effect of GanDouLing (GDL) on neural stem cell (NSC) function in a mouse model of WD. NSCs...

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Veröffentlicht in:	Bioscience reports 2021-01, Vol.41 (1)
Hauptverfasser:	Dong, Ting, Wu, Ming-Cai, Tang, Lu-Lu, Jiang, Hai-Lin, Zhou, Ping, Kuang, Chun-Jun, Tian, Li-Wei, Yang, Wen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Apoptosis - drug effects Cell Differentiation Cell proliferation Cell Proliferation - drug effects Cells, Cultured Chinese medicine Copper Differentiation Disease Models, Animal Drug dosages Ethanol Female Glial fibrillary acidic protein Hepatolenticular Degeneration - pathology Hippocampus Inflammasomes Liver Metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Microtubule-associated protein 2 Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - drug effects Neurogenesis Neuroprotective Agents - pharmacology Neuroscience Proteins Pyrin protein Stem Cells Therapeutics & Molecular Medicine Tubulin Western blotting Wilson's disease
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