Minocycline differentially modulates human spatial memory systems

Microglia play a critical role in many processes fundamental to learning and memory in health and are implicated in Alzheimer's pathogenesis. Minocycline, a centrally-penetrant tetracycline antibiotic, inhibits microglial activation and enhances long-term potentiation, synaptic plasticity, neur...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2020-12, Vol.45 (13), p.2162-2169
Hauptverfasser:	Berens, Sam C, Bird, Chris M, Harrison, Neil A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal behavior Antibiotics Brain research Clinical trials Cognition & reasoning Cognitive ability Functional magnetic resonance imaging Gene expression Hippocampal plasticity Hippocampus Humans Immunological memory Learning Long-term potentiation Male Memory Memory Disorders Microglia Minocycline Minocycline - pharmacology Neostriatum Neurodegenerative diseases Neurogenesis Spatial Memory Synaptic plasticity Tumor necrosis factor-TNF
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