Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy

Tissue-resident memory CD8+ T cells (Trm) provide host protection through continuous surveillance of non-lymphoid tissues. Using single-cell RNA-sequencing (scRNA-seq) and genetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo ti...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2020-05, Vol.52 (5), p.808-824.e7
Hauptverfasser:	Milner, J. Justin, Toma, Clara, He, Zhaoren, Kurd, Nadia S., Nguyen, Quynh P., McDonald, Bryan, Quezada, Lauren, Widjaja, Christella E., Witherden, Deborah A., Crowl, John T., Shaw, Laura A., Yeo, Gene W., Chang, John T., Omilusik, Kyla D., Goldrath, Ananda W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Bacterial diseases CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - virology Cells, Cultured Cytokines Gene expression Gene sequencing Heterogeneity Immunologic Memory - immunology Immunological memory Immunotherapy Immunotherapy - methods Infections Inhibitor of Differentiation Protein 2 - genetics Inhibitor of Differentiation Protein 2 - immunology Inhibitor of Differentiation Protein 2 - metabolism Inhibitor of Differentiation Proteins - genetics Inhibitor of Differentiation Proteins - immunology Inhibitor of Differentiation Proteins - metabolism Intestine Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - immunology Lymphocytic choriomeningitis virus - physiology Lymphoid tissue Malignancy Memory cells memory T cell Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neoplasms - immunology Neoplasms - therapy Population Populations Positive Regulatory Domain I-Binding Factor 1 - genetics Positive Regulatory Domain I-Binding Factor 1 - immunology Positive Regulatory Domain I-Binding Factor 1 - metabolism Principal components analysis Ribonucleic acid RNA single-cell RNA-sequencing Spleen T cell Tissue analysis tissue-resident memory T cells Tissues Transcription Transcription factors tumor immunity Vaccination
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