Low Serum Naproxen Concentrations Are Associated with Minimal Pain Relief: A Preliminary Study in Women with Dysmenorrhea

Abstract Objective Incomplete pain relief after administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is common, but it is unknown whether malabsorption or heightened metabolism contributes to NSAID resistance. To explain the etiology of NSAID resistance, we evaluated naproxen absorption a...

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Veröffentlicht in:	Pain medicine (Malden, Mass.) Mass.), 2020-11, Vol.21 (11), p.3102-3108
Hauptverfasser:	Oladosu, Folabomi A, Tu, Frank F, Garrison, Ellen F, Dillane, Katlyn E, Roth, Genevieve E, Hellman, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Analgesics - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Complications and side effects Drug metabolism Drug resistance Drug therapy Dysmenorrhea Dysmenorrhea - drug therapy Etiology Female General & Selected Populations Section Humans Inflammation Malabsorption Menstruation Metabolism Metabolites Naproxen Naproxen - therapeutic use Nonsteroidal anti-inflammatory drugs Pain Patient outcomes Pharmacology, Experimental Physiological aspects Pilot Projects Womens health
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