Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer

Background Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT’s different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously c...

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Veröffentlicht in:	British journal of cancer 2021-01, Vol.124 (1), p.281-289
Hauptverfasser:	Siddiqui, Mohammad Aarif, Gollavilli, Paradesi Naidu, Ramesh, Vignesh, Parma, Beatrice, Schwab, Annemarie, Vazakidou, Maria Eleni, Natesan, Ramakrishnan, Saatci, Ozge, Rapa, Ida, Bironzo, Paolo, Schuhwerk, Harald, Asangani, Irfan Ahmed, Sahin, Ozgur, Volante, Marco, Ceppi, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1612/1350 631/67/1857 Animals Axl protein Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Chemoresistance Chemotherapy Drug Resistance Epidemiology Epithelial-Mesenchymal Transition - physiology Folic acid Humans Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - pathology Medical prognosis Mesenchyme Metastases Metastasis Mice Molecular Medicine Non-small cell lung carcinoma Oncology Osteonectin Phenotype Phenotypes Ribonucleic acid RNA Small cell lung carcinoma Thymidylate synthase Thymidylate Synthase - metabolism Transcription factors
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