First structure–activity relationship analysis of SARS-CoV-2 virus main protease (Mpro) inhibitors: an endeavor on COVID-19 drug discovery

Main protease (Mpro) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) intervenes in the replication and transcription processes of the virus. Hence, it is a lucrative target for anti-viral drug development. In this study, molecular modeling analyses were performed on the structure act...

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Veröffentlicht in:	Molecular diversity 2021-08, Vol.25 (3), p.1827-1838
Hauptverfasser:	Amin, Sk. Abdul, Banerjee, Suvankar, Singh, Samayaditya, Qureshi, Insaf Ahmed, Gayen, Shovanlal, Jha, Tarun
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Availability Biomedical and Life Sciences Coronavirus 3C Proteases - antagonists & inhibitors Coronavirus 3C Proteases - chemistry Coronaviruses Drug development Life Sciences Models, Molecular Organic Chemistry Original Original Article Pharmacy Polymer Sciences Protease Inhibitors - chemistry Protease Inhibitors - pharmacokinetics Protease Inhibitors - pharmacology Protein Conformation SARS-CoV-2 - drug effects SARS-CoV-2 - enzymology Severe acute respiratory syndrome coronavirus 2 Structure-Activity Relationship
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