Opsin 3-G αs Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2

Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling mechanisms of photorelaxation. We confirmed the functional role...

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Veröffentlicht in:American journal of respiratory cell and molecular biology 2021-01, Vol.64 (1), p.59-68
Hauptverfasser: Wu, Amy D, Dan, William, Zhang, Yi, Vemaraju, Shruti, Upton, Brian A, Lang, Richard A, Buhr, Ethan D, Berkowitz, Dan E, Gallos, George, Emala, Charles W, Yim, Peter D
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Sprache:eng
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Zusammenfassung:Recently, we characterized blue light-mediated relaxation (photorelaxation) of airway smooth muscle (ASM) and implicated the involvement of opsin 3 (OPN3), an atypical opsin. In the present study, we characterized the cellular signaling mechanisms of photorelaxation. We confirmed the functional role of OPN3 in blue light photorelaxation using trachea from OPN3 null mice (maximal relaxation 52 ± 13% compared with wild-type mice 90 ± 4.3%,  
ISSN:1044-1549
1535-4989
DOI:10.1165/rcmb.2020-0392OC