The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism
Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases. The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism. A total number of 150 individuals...
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| Veröffentlicht in: | Medical archives (Sarajevo, Bosnia and Herzegovina) Bosnia and Herzegovina), 2020-10, Vol.74 (5), p.359-362 |
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| container_title | Medical archives (Sarajevo, Bosnia and Herzegovina) |
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| creator | Sulejmanovic, Maja Begić, Amela Mujaric-Bousbia, Fatima Salkic, Sabina Ramas, Almedina |
| description | Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases.
The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism.
A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG).
Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p |
| doi_str_mv | 10.5455/medarh.2020.74.359-362 |
| format | Article |
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The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism.
A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG).
Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p<0,01). Moreover, there was a highly significant difference between patients with AITD and patients without AITD (20,76±6,31ng/ml vs. 24,37±9,05ng/ml, respectively; p<0,01). The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001). Serum TSH were significantly higher in group I (p< 0,001).
Significantly low levels of vitamin D were documented in patients with AITD that were related to the presence of anti-thyroid antibodies and higher level thyroid-stimulation hormone (TSH), suggesting the involvement of vitamin D in the pathogenesis of AITD and the advisability of supplementation.</description><identifier>ISSN: 0350-199X</identifier><identifier>EISSN: 1986-5961</identifier><identifier>DOI: 10.5455/medarh.2020.74.359-362</identifier><identifier>PMID: 33424090</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Academy of Medical Sciences of Bosnia and Herzegovina</publisher><subject>Adult ; Aged ; Autoantibodies - blood ; Female ; Healthy Volunteers ; Humans ; Hypothyroidism - etiology ; Hypothyroidism - physiopathology ; Immunoglobulins, Thyroid-Stimulating - blood ; Male ; Middle Aged ; Original Paper ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications</subject><ispartof>Medical archives (Sarajevo, Bosnia and Herzegovina), 2020-10, Vol.74 (5), p.359-362</ispartof><rights>2020 Maja Sulejmanovic, Amra Jakubovic-Cickusic, Amela Begic, Fatima Mujaric-Bousbia, Sabina Salkic, Almedina Ramas.</rights><rights>2020 Maja Sulejmanovic, Amra Jakubovic-Cickusic, Amela Begic, Fatima Mujaric-Bousbia, Sabina Salkic, Almedina Ramas 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3292-3e98b8ac08a91e877175fe117e1a5cadead3f88e11a40799137d5b3051e4775c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780811/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780811/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33424090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sulejmanovic, Maja</creatorcontrib><creatorcontrib>Begić, Amela</creatorcontrib><creatorcontrib>Mujaric-Bousbia, Fatima</creatorcontrib><creatorcontrib>Salkic, Sabina</creatorcontrib><creatorcontrib>Ramas, Almedina</creatorcontrib><title>The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism</title><title>Medical archives (Sarajevo, Bosnia and Herzegovina)</title><addtitle>Med Arch</addtitle><description>Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases.
The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism.
A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG).
Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p<0,01). Moreover, there was a highly significant difference between patients with AITD and patients without AITD (20,76±6,31ng/ml vs. 24,37±9,05ng/ml, respectively; p<0,01). The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001). Serum TSH were significantly higher in group I (p< 0,001).
Significantly low levels of vitamin D were documented in patients with AITD that were related to the presence of anti-thyroid antibodies and higher level thyroid-stimulation hormone (TSH), suggesting the involvement of vitamin D in the pathogenesis of AITD and the advisability of supplementation.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Hypothyroidism - etiology</subject><subject>Hypothyroidism - physiopathology</subject><subject>Immunoglobulins, Thyroid-Stimulating - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><issn>0350-199X</issn><issn>1986-5961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkG9LwzAQh4Mobk6_wsgXaE2apkneCPPvhIEiU_RVSNurjbRpaepk396O6tBXd9zx_O54EJpTEvKY8_MactOVYUQiEoo4ZFwFLIkO0JQqmQRcJfQQTQnjJKBKvU7QifcfhHAlInWMJozFUUwUmaK3dQn4CSrT28b50rb4EvovAIfX5bZrbI4Xrrdpk1vw2Lgcv9je1Nbha7yCDVR4aB87W5tui5fbtulHyvr6FB0VpvJw9lNn6Pn2Zn21DFYPd_dXi1WQsUhFAQMlU2kyIo2iIIWgghdAqQBqeGZyMDkrpBwmJiZCKcpEzlNGOIVYCJ6xGboYc9vPdLCSges7U-l2fEo3xur_G2dL_d5stBCSSEqHgGQMyLrG-w6KPUuJ3snWo2y9k61FrAfZepA9gPO_l_fYr132DfBDfvY</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Sulejmanovic, Maja</creator><creator>Begić, Amela</creator><creator>Mujaric-Bousbia, Fatima</creator><creator>Salkic, Sabina</creator><creator>Ramas, Almedina</creator><general>Academy of Medical Sciences of Bosnia and Herzegovina</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism</title><author>Sulejmanovic, Maja ; Begić, Amela ; Mujaric-Bousbia, Fatima ; Salkic, Sabina ; Ramas, Almedina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3292-3e98b8ac08a91e877175fe117e1a5cadead3f88e11a40799137d5b3051e4775c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Hypothyroidism - etiology</topic><topic>Hypothyroidism - physiopathology</topic><topic>Immunoglobulins, Thyroid-Stimulating - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sulejmanovic, Maja</creatorcontrib><creatorcontrib>Begić, Amela</creatorcontrib><creatorcontrib>Mujaric-Bousbia, Fatima</creatorcontrib><creatorcontrib>Salkic, Sabina</creatorcontrib><creatorcontrib>Ramas, Almedina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical archives (Sarajevo, Bosnia and Herzegovina)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sulejmanovic, Maja</au><au>Begić, Amela</au><au>Mujaric-Bousbia, Fatima</au><au>Salkic, Sabina</au><au>Ramas, Almedina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism</atitle><jtitle>Medical archives (Sarajevo, Bosnia and Herzegovina)</jtitle><addtitle>Med Arch</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>74</volume><issue>5</issue><spage>359</spage><epage>362</epage><pages>359-362</pages><issn>0350-199X</issn><eissn>1986-5961</eissn><abstract>Vitamin D deficiency is a global health problem. Its deficiency has been reported to be associated with different autoimmune diseases.
The aim of this study was to evaluate the relationship between vitamin D level and thyroid antibodies in autoimmune hypothyroidism.
A total number of 150 individuals were enrolled in this study. They were divided into the fallowing groups: group I included 50 patients with autoimmune thyroid disease (AITD), group II included 50 patients without autoimmune thyroid disease. Group III included 50 apparently healthy participants representing a control group. All participants underwent a detailed clinical examination and laboratory tests including, 25 (OH) vitamin D, thyroid-stimulating hormone (TSH) and thyroid autoantibodies assessment, including anti-thyroid peroxidase antibodies (anti-TPO) and anti-thyroglobulin antibodies (anti-TG).
Serum levels of 25 (OH) vitamin D recorded a highly significant difference between the studies groups (20,76±6,31 ng/ml in group I vs. 24,37±9,05ng/ml in group II vs. 24,57±6,45ng/ml in group III, p<0,01). Moreover, there was a highly significant difference between patients with AITD and patients without AITD (20,76±6,31ng/ml vs. 24,37±9,05ng/ml, respectively; p<0,01). The concentration of anti-TPO and anti-TG antibodies were statistically significant higher in patients with vitamin D deficiency (p< 0,001). Serum TSH were significantly higher in group I (p< 0,001).
Significantly low levels of vitamin D were documented in patients with AITD that were related to the presence of anti-thyroid antibodies and higher level thyroid-stimulation hormone (TSH), suggesting the involvement of vitamin D in the pathogenesis of AITD and the advisability of supplementation.</abstract><cop>Bosnia and Herzegovina</cop><pub>Academy of Medical Sciences of Bosnia and Herzegovina</pub><pmid>33424090</pmid><doi>10.5455/medarh.2020.74.359-362</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Autoantibodies - blood Female Healthy Volunteers Humans Hypothyroidism - etiology Hypothyroidism - physiopathology Immunoglobulins, Thyroid-Stimulating - blood Male Middle Aged Original Paper Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications |
| title | The Relationship Between Thyroid Antibodies and Vitamin D Level in Primary Hypothyroidism |
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