MiR‐22 modulates the expression of lipogenesis‐related genes and promotes hepatic steatosis in vitro

We observed that miR‐22 can promote hepatic steatosis. Conversely, steatosis was alleviated after inhibition of miR‐22, indicating that miR‐22 is involved in fat deposition. Furthermore, miR‐22 was validated to have effects on downstream lipid metabolism‐related genes, revealing the pathways through...

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Veröffentlicht in:	FEBS open bio 2021-01, Vol.11 (1), p.322-332
Hauptverfasser:	Yang, Zhuo, Qin, Wen, Huo, Junsheng, Zhuo, Qin, Wang, Jingbo, Wang, Liyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antitumor activity Carbon dioxide Cell lines Cholesterol Dehydrogenases Denaturation Disease control Fatty acids Fatty liver Forkhead protein FOXO1 protein Glyceraldehyde Glyceraldehyde-3-phosphate dehydrogenase High fat diet Homeostasis Lipid metabolism Lipids Lipogenesis Liver diseases Metabolism MicroRNAs miRNA miR‐22 nonalcoholic fatty liver disease Obesity Proteins Sirt1 SIRT1 protein Steatosis Sterol regulatory element-binding protein Sterols
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