Pseudogene KRT17P3 drives cisplatin resistance of human NSCLC cells by modulating miR‐497‐5p/mTOR

Chemoresistance is a major obstacle in non–small cell lung cancer (NSCLC) treatment. The pseudogene keratin 17 pseudogene 3 (KRT17P3) has been previously shown to be upregulated in lung cancer tissues of patients with cisplatin resistance. In the present study, RT‐qPCR was performed to evaluate KRT1...

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Veröffentlicht in:	Cancer science 2021-01, Vol.112 (1), p.275-286
Hauptverfasser:	Hou, Zhibo, Wang, Yi, Xia, Ning, Lv, Tangfeng, Yuan, Xiaoqin, Song, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Apoptosis Bioinformatics Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell viability Cell, Molecular, and Stem Cell Biology Chemoresistance Chemotherapy Chromosome 5 Cisplatin Cisplatin - therapeutic use Drug resistance Drug Resistance, Neoplasm - genetics Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - genetics Heterografts Humans Immunoprecipitation Keratin Keratin-17 - genetics KRT17P3 Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Male Metastasis Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR‐497‐5p mTOR Non-small cell lung carcinoma non–small‐cell lung cancer Original Peripheral blood Plasma Plasmids Polymerase chain reaction Pseudogenes - genetics Ribonucleic acid RNA Small cell lung carcinoma Software TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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