Anterior cingulate cortex and dorsal hippocampal glutamate receptors mediate generalized fear in female rats

•Estradiol acts within the anterior cingulate cortex (ACC) but not the ventral CA1 (vCA1) to induce context fear generalization.•Blocking AMPA or NMDA receptors within the dCA1 or ACC prior to testing reduces estradiol induced generalization.•Blocking GluN2B containing NMDA receptors within the dCA1...

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Veröffentlicht in:	Psychoneuroendocrinology 2019-09, Vol.107, p.109-118
Hauptverfasser:	Adkins, Jordan M., Lynch, Joseph F., Hagerdorn, Payton, Esterhuizen, Monique, Jasnow, Aaron M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anterior cingulate cortex CA1 Region, Hippocampal - metabolism Estradiol Estradiol - metabolism Fear - physiology Female Females Generalization Generalization, Psychological - drug effects Generalization, Psychological - physiology Glutamate Glutamic Acid - metabolism Glutamic Acid - physiology Gyrus Cinguli - metabolism Hippocampus Hippocampus - metabolism Memory - physiology Ovariectomy Rats Rats, Long-Evans Receptors, Glutamate - metabolism Receptors, N-Methyl-D-Aspartate - metabolism
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