FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs
Abstract The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research commun...
Gespeichert in:
| Veröffentlicht in: | Nucleic acids research 2021-01, Vol.49 (D1), p.D892-D898 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | D898 |
|---|---|
| container_issue | D1 |
| container_start_page | D892 |
| container_title | Nucleic acids research |
| container_volume | 49 |
| creator | Abugessaisa, Imad Ramilowski, Jordan A Lizio, Marina Severin, Jesicca Hasegawa, Akira Harshbarger, Jayson Kondo, Atsushi Noguchi, Shuhei Yip, Chi Wai Ooi, Jasmine Li Ching Tagami, Michihira Hori, Fumi Agrawal, Saumya Hon, Chung Chau Cardon, Melissa Ikeda, Shuya Ono, Hiromasa Bono, Hidemasa Kato, Masaki Hashimoto, Kosuke Bonetti, Alessandro Kato, Masaki Kobayashi, Norio Shin, Jay de Hoon, Michiel Hayashizaki, Yoshihide Carninci, Piero Kawaji, Hideya Kasukawa, Takeya |
| description | Abstract
The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/. |
| doi_str_mv | 10.1093/nar/gkaa1054 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7779024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/nar/gkaa1054</oup_id><sourcerecordid>2463099612</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-a8131a07e282a3afda6961b7b2325a4b34b57a738f8c6371128e3f7d074bc9153</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq0KVBbaG2fkGxwI66_ECQek1aq0legiVfRsTRxnMWTtYDuo_Pu62gWVS08zo3nmnRm9CB1TckFJw-cOwnz9CEBJKT6gGeUVK0RTsT00I5yUBSWiPkCHMT4QQgUtxUd0wDmjtK7EDNnrxeru9gc2LpkQMSPpHr8YCJfY_B7BResd9j1OIec62DH5jdUY0gDRRAyuw_3kdMoYDLl0PkHazTjvCu0769b452oRP6H9HoZoPu_iEfp1_eVu-a24uf36fbm4KbSoWSqgppwCkYbVDDj0HVRNRVvZMs5KEC0XbSlB8rqvdcUlpaw2vJcdkaLVDS35Ebra6o5TuzGdzp8FGNQY7AbCi_Jg1fuOs_dq7Z-VlLIhTGSBs51A8E-TiUltbNRmGMAZP0XFRMVJk49iGT3fojr4GIPp39ZQov66o7I76tWdjJ_8e9ob_GpHBk63gJ_G_0v9AbOmmlY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2463099612</pqid></control><display><type>article</type><title>FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Oxford Journals Open Access Collection</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Abugessaisa, Imad ; Ramilowski, Jordan A ; Lizio, Marina ; Severin, Jesicca ; Hasegawa, Akira ; Harshbarger, Jayson ; Kondo, Atsushi ; Noguchi, Shuhei ; Yip, Chi Wai ; Ooi, Jasmine Li Ching ; Tagami, Michihira ; Hori, Fumi ; Agrawal, Saumya ; Hon, Chung Chau ; Cardon, Melissa ; Ikeda, Shuya ; Ono, Hiromasa ; Bono, Hidemasa ; Kato, Masaki ; Hashimoto, Kosuke ; Bonetti, Alessandro ; Kato, Masaki ; Kobayashi, Norio ; Shin, Jay ; de Hoon, Michiel ; Hayashizaki, Yoshihide ; Carninci, Piero ; Kawaji, Hideya ; Kasukawa, Takeya</creator><creatorcontrib>Abugessaisa, Imad ; Ramilowski, Jordan A ; Lizio, Marina ; Severin, Jesicca ; Hasegawa, Akira ; Harshbarger, Jayson ; Kondo, Atsushi ; Noguchi, Shuhei ; Yip, Chi Wai ; Ooi, Jasmine Li Ching ; Tagami, Michihira ; Hori, Fumi ; Agrawal, Saumya ; Hon, Chung Chau ; Cardon, Melissa ; Ikeda, Shuya ; Ono, Hiromasa ; Bono, Hidemasa ; Kato, Masaki ; Hashimoto, Kosuke ; Bonetti, Alessandro ; Kato, Masaki ; Kobayashi, Norio ; Shin, Jay ; de Hoon, Michiel ; Hayashizaki, Yoshihide ; Carninci, Piero ; Kawaji, Hideya ; Kasukawa, Takeya</creatorcontrib><description>Abstract
The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/.</description><identifier>ISSN: 0305-1048</identifier><identifier>EISSN: 1362-4962</identifier><identifier>DOI: 10.1093/nar/gkaa1054</identifier><identifier>PMID: 33211864</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Binding Sites ; Chromatin - metabolism ; Database Issue ; Drosophila - genetics ; Fibroblasts - cytology ; Fibroblasts - metabolism ; Genome ; Humans ; Metadata ; Mice ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Molecular Sequence Annotation ; Promoter Regions, Genetic ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Transcription Factors - metabolism ; Transcriptome - genetics ; User-Computer Interface</subject><ispartof>Nucleic acids research, 2021-01, Vol.49 (D1), p.D892-D898</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. 2021</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-a8131a07e282a3afda6961b7b2325a4b34b57a738f8c6371128e3f7d074bc9153</citedby><cites>FETCH-LOGICAL-c482t-a8131a07e282a3afda6961b7b2325a4b34b57a738f8c6371128e3f7d074bc9153</cites><orcidid>0000-0002-3156-6416 ; 0000-0001-7458-801X ; 0000-0003-1274-208X ; 0000-0001-5085-0802 ; 0000-0001-7202-7243</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779024/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779024/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1603,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33211864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abugessaisa, Imad</creatorcontrib><creatorcontrib>Ramilowski, Jordan A</creatorcontrib><creatorcontrib>Lizio, Marina</creatorcontrib><creatorcontrib>Severin, Jesicca</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Harshbarger, Jayson</creatorcontrib><creatorcontrib>Kondo, Atsushi</creatorcontrib><creatorcontrib>Noguchi, Shuhei</creatorcontrib><creatorcontrib>Yip, Chi Wai</creatorcontrib><creatorcontrib>Ooi, Jasmine Li Ching</creatorcontrib><creatorcontrib>Tagami, Michihira</creatorcontrib><creatorcontrib>Hori, Fumi</creatorcontrib><creatorcontrib>Agrawal, Saumya</creatorcontrib><creatorcontrib>Hon, Chung Chau</creatorcontrib><creatorcontrib>Cardon, Melissa</creatorcontrib><creatorcontrib>Ikeda, Shuya</creatorcontrib><creatorcontrib>Ono, Hiromasa</creatorcontrib><creatorcontrib>Bono, Hidemasa</creatorcontrib><creatorcontrib>Kato, Masaki</creatorcontrib><creatorcontrib>Hashimoto, Kosuke</creatorcontrib><creatorcontrib>Bonetti, Alessandro</creatorcontrib><creatorcontrib>Kato, Masaki</creatorcontrib><creatorcontrib>Kobayashi, Norio</creatorcontrib><creatorcontrib>Shin, Jay</creatorcontrib><creatorcontrib>de Hoon, Michiel</creatorcontrib><creatorcontrib>Hayashizaki, Yoshihide</creatorcontrib><creatorcontrib>Carninci, Piero</creatorcontrib><creatorcontrib>Kawaji, Hideya</creatorcontrib><creatorcontrib>Kasukawa, Takeya</creatorcontrib><title>FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs</title><title>Nucleic acids research</title><addtitle>Nucleic Acids Res</addtitle><description>Abstract
The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Chromatin - metabolism</subject><subject>Database Issue</subject><subject>Drosophila - genetics</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - metabolism</subject><subject>Genome</subject><subject>Humans</subject><subject>Metadata</subject><subject>Mice</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Molecular Sequence Annotation</subject><subject>Promoter Regions, Genetic</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptome - genetics</subject><subject>User-Computer Interface</subject><issn>0305-1048</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq0KVBbaG2fkGxwI66_ECQek1aq0legiVfRsTRxnMWTtYDuo_Pu62gWVS08zo3nmnRm9CB1TckFJw-cOwnz9CEBJKT6gGeUVK0RTsT00I5yUBSWiPkCHMT4QQgUtxUd0wDmjtK7EDNnrxeru9gc2LpkQMSPpHr8YCJfY_B7BResd9j1OIec62DH5jdUY0gDRRAyuw_3kdMoYDLl0PkHazTjvCu0769b452oRP6H9HoZoPu_iEfp1_eVu-a24uf36fbm4KbSoWSqgppwCkYbVDDj0HVRNRVvZMs5KEC0XbSlB8rqvdcUlpaw2vJcdkaLVDS35Ebra6o5TuzGdzp8FGNQY7AbCi_Jg1fuOs_dq7Z-VlLIhTGSBs51A8E-TiUltbNRmGMAZP0XFRMVJk49iGT3fojr4GIPp39ZQov66o7I76tWdjJ_8e9ob_GpHBk63gJ_G_0v9AbOmmlY</recordid><startdate>20210108</startdate><enddate>20210108</enddate><creator>Abugessaisa, Imad</creator><creator>Ramilowski, Jordan A</creator><creator>Lizio, Marina</creator><creator>Severin, Jesicca</creator><creator>Hasegawa, Akira</creator><creator>Harshbarger, Jayson</creator><creator>Kondo, Atsushi</creator><creator>Noguchi, Shuhei</creator><creator>Yip, Chi Wai</creator><creator>Ooi, Jasmine Li Ching</creator><creator>Tagami, Michihira</creator><creator>Hori, Fumi</creator><creator>Agrawal, Saumya</creator><creator>Hon, Chung Chau</creator><creator>Cardon, Melissa</creator><creator>Ikeda, Shuya</creator><creator>Ono, Hiromasa</creator><creator>Bono, Hidemasa</creator><creator>Kato, Masaki</creator><creator>Hashimoto, Kosuke</creator><creator>Bonetti, Alessandro</creator><creator>Kato, Masaki</creator><creator>Kobayashi, Norio</creator><creator>Shin, Jay</creator><creator>de Hoon, Michiel</creator><creator>Hayashizaki, Yoshihide</creator><creator>Carninci, Piero</creator><creator>Kawaji, Hideya</creator><creator>Kasukawa, Takeya</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3156-6416</orcidid><orcidid>https://orcid.org/0000-0001-7458-801X</orcidid><orcidid>https://orcid.org/0000-0003-1274-208X</orcidid><orcidid>https://orcid.org/0000-0001-5085-0802</orcidid><orcidid>https://orcid.org/0000-0001-7202-7243</orcidid></search><sort><creationdate>20210108</creationdate><title>FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs</title><author>Abugessaisa, Imad ; Ramilowski, Jordan A ; Lizio, Marina ; Severin, Jesicca ; Hasegawa, Akira ; Harshbarger, Jayson ; Kondo, Atsushi ; Noguchi, Shuhei ; Yip, Chi Wai ; Ooi, Jasmine Li Ching ; Tagami, Michihira ; Hori, Fumi ; Agrawal, Saumya ; Hon, Chung Chau ; Cardon, Melissa ; Ikeda, Shuya ; Ono, Hiromasa ; Bono, Hidemasa ; Kato, Masaki ; Hashimoto, Kosuke ; Bonetti, Alessandro ; Kato, Masaki ; Kobayashi, Norio ; Shin, Jay ; de Hoon, Michiel ; Hayashizaki, Yoshihide ; Carninci, Piero ; Kawaji, Hideya ; Kasukawa, Takeya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-a8131a07e282a3afda6961b7b2325a4b34b57a738f8c6371128e3f7d074bc9153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Chromatin - metabolism</topic><topic>Database Issue</topic><topic>Drosophila - genetics</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - metabolism</topic><topic>Genome</topic><topic>Humans</topic><topic>Metadata</topic><topic>Mice</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Molecular Sequence Annotation</topic><topic>Promoter Regions, Genetic</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Transcriptome - genetics</topic><topic>User-Computer Interface</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abugessaisa, Imad</creatorcontrib><creatorcontrib>Ramilowski, Jordan A</creatorcontrib><creatorcontrib>Lizio, Marina</creatorcontrib><creatorcontrib>Severin, Jesicca</creatorcontrib><creatorcontrib>Hasegawa, Akira</creatorcontrib><creatorcontrib>Harshbarger, Jayson</creatorcontrib><creatorcontrib>Kondo, Atsushi</creatorcontrib><creatorcontrib>Noguchi, Shuhei</creatorcontrib><creatorcontrib>Yip, Chi Wai</creatorcontrib><creatorcontrib>Ooi, Jasmine Li Ching</creatorcontrib><creatorcontrib>Tagami, Michihira</creatorcontrib><creatorcontrib>Hori, Fumi</creatorcontrib><creatorcontrib>Agrawal, Saumya</creatorcontrib><creatorcontrib>Hon, Chung Chau</creatorcontrib><creatorcontrib>Cardon, Melissa</creatorcontrib><creatorcontrib>Ikeda, Shuya</creatorcontrib><creatorcontrib>Ono, Hiromasa</creatorcontrib><creatorcontrib>Bono, Hidemasa</creatorcontrib><creatorcontrib>Kato, Masaki</creatorcontrib><creatorcontrib>Hashimoto, Kosuke</creatorcontrib><creatorcontrib>Bonetti, Alessandro</creatorcontrib><creatorcontrib>Kato, Masaki</creatorcontrib><creatorcontrib>Kobayashi, Norio</creatorcontrib><creatorcontrib>Shin, Jay</creatorcontrib><creatorcontrib>de Hoon, Michiel</creatorcontrib><creatorcontrib>Hayashizaki, Yoshihide</creatorcontrib><creatorcontrib>Carninci, Piero</creatorcontrib><creatorcontrib>Kawaji, Hideya</creatorcontrib><creatorcontrib>Kasukawa, Takeya</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abugessaisa, Imad</au><au>Ramilowski, Jordan A</au><au>Lizio, Marina</au><au>Severin, Jesicca</au><au>Hasegawa, Akira</au><au>Harshbarger, Jayson</au><au>Kondo, Atsushi</au><au>Noguchi, Shuhei</au><au>Yip, Chi Wai</au><au>Ooi, Jasmine Li Ching</au><au>Tagami, Michihira</au><au>Hori, Fumi</au><au>Agrawal, Saumya</au><au>Hon, Chung Chau</au><au>Cardon, Melissa</au><au>Ikeda, Shuya</au><au>Ono, Hiromasa</au><au>Bono, Hidemasa</au><au>Kato, Masaki</au><au>Hashimoto, Kosuke</au><au>Bonetti, Alessandro</au><au>Kato, Masaki</au><au>Kobayashi, Norio</au><au>Shin, Jay</au><au>de Hoon, Michiel</au><au>Hayashizaki, Yoshihide</au><au>Carninci, Piero</au><au>Kawaji, Hideya</au><au>Kasukawa, Takeya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>2021-01-08</date><risdate>2021</risdate><volume>49</volume><issue>D1</issue><spage>D892</spage><epage>D898</epage><pages>D892-D898</pages><issn>0305-1048</issn><eissn>1362-4962</eissn><abstract>Abstract
The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33211864</pmid><doi>10.1093/nar/gkaa1054</doi><orcidid>https://orcid.org/0000-0002-3156-6416</orcidid><orcidid>https://orcid.org/0000-0001-7458-801X</orcidid><orcidid>https://orcid.org/0000-0003-1274-208X</orcidid><orcidid>https://orcid.org/0000-0001-5085-0802</orcidid><orcidid>https://orcid.org/0000-0001-7202-7243</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1048 |
| ispartof | Nucleic acids research, 2021-01, Vol.49 (D1), p.D892-D898 |
| issn | 0305-1048 1362-4962 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7779024 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Oxford Journals Open Access Collection; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Binding Sites Chromatin - metabolism Database Issue Drosophila - genetics Fibroblasts - cytology Fibroblasts - metabolism Genome Humans Metadata Mice MicroRNAs - genetics MicroRNAs - metabolism Molecular Sequence Annotation Promoter Regions, Genetic RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcription Factors - metabolism Transcriptome - genetics User-Computer Interface |
| title | FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T10%3A59%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=FANTOM%20enters%2020th%20year:%20expansion%20of%20transcriptomic%20atlases%20and%20functional%20annotation%20of%20non-coding%20RNAs&rft.jtitle=Nucleic%20acids%20research&rft.au=Abugessaisa,%20Imad&rft.date=2021-01-08&rft.volume=49&rft.issue=D1&rft.spage=D892&rft.epage=D898&rft.pages=D892-D898&rft.issn=0305-1048&rft.eissn=1362-4962&rft_id=info:doi/10.1093/nar/gkaa1054&rft_dat=%3Cproquest_pubme%3E2463099612%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2463099612&rft_id=info:pmid/33211864&rft_oup_id=10.1093/nar/gkaa1054&rfr_iscdi=true |