Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study
Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases. To investigate the effects of a...
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| Veröffentlicht in: | International Journal of Reproductive BioMedicine 2020-12, Vol.18 (12), p.1029-1038 |
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| container_title | International Journal of Reproductive BioMedicine |
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| creator | Aslfalah, Hadise Jamilian, Mehri Ansarihadipour, Hadi Abdollahi, Mahdi Khosrowbeygi, Ali |
| description | Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases.
To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM.
Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value
0.05 was considered as statistically significant.
The values of TyG index (p
0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM. |
| doi_str_mv | 10.18502/ijrm.v18i12.8024 |
| format | Article |
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To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM.
Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value
0.05 was considered as statistically significant.
The values of TyG index (p
0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM.</description><identifier>ISSN: 2476-4108</identifier><identifier>EISSN: 2476-3772</identifier><identifier>DOI: 10.18502/ijrm.v18i12.8024</identifier><identifier>PMID: 33426413</identifier><language>eng</language><publisher>Iran: Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</publisher><subject>Cellulose acetate ; Cholesterol ; Gestational diabetes ; Lipids ; lipoic acid, gestational diabetes, lipids, triglycerides, cholesterol ; Womens health</subject><ispartof>International Journal of Reproductive BioMedicine, 2020-12, Vol.18 (12), p.1029-1038</ispartof><rights>Copyright © 2020 Aslfalah et al.</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020 Aslfalah et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-5efb3f5b5ac64a2196c992c8d1b8db3347bd690f9b594b63d448c373f197be263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778749/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778749/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33426413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslfalah, Hadise</creatorcontrib><creatorcontrib>Jamilian, Mehri</creatorcontrib><creatorcontrib>Ansarihadipour, Hadi</creatorcontrib><creatorcontrib>Abdollahi, Mahdi</creatorcontrib><creatorcontrib>Khosrowbeygi, Ali</creatorcontrib><title>Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study</title><title>International Journal of Reproductive BioMedicine</title><addtitle>Int J Reprod Biomed</addtitle><description>Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases.
To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM.
Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value
0.05 was considered as statistically significant.
The values of TyG index (p
0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM.</description><subject>Cellulose acetate</subject><subject>Cholesterol</subject><subject>Gestational diabetes</subject><subject>Lipids</subject><subject>lipoic acid, gestational diabetes, lipids, triglycerides, cholesterol</subject><subject>Womens health</subject><issn>2476-4108</issn><issn>2476-3772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNpdUl1rFDEUHUSxZe0P8EUCvviy6-RjMhkfhFKqFgq-6HO4-drNkpmMSaalP8T_a7a7FiuEJNx7ziH35DTNW9xusOha8tHv07i5w8JjshEtYS-ac8J6vqZ9T16e7gy34qy5yHnfti3mHcaEvm7OKGWEM0zPm9_XzlldUHQIwryDdfBz9BqB9gblZZ6DHe1UoPg4obrKzqIKqc05ReeDRTCZUyUdUBn5Cd3HSkL3vuzQ1uYjGwIyHpQtNqPRhuDLkj-hS6SDn7yu3ZJ83XNZzMOb5pWDkO3F6Vw1P79c_7j6tr79_vXm6vJ2rdlAy7qzTlHXqQ40Z0DwwPUwEC0MVsKoOmSvDB9aN6huYIpTw5jQtKcOD72yhNNVc3PUNRH2ck5-hPQgI3j5WIhpKyEVr4OVwnUGAAYwg2XGKCUEVdxwwyi3CkjV-nzUmhc1WqOrawnCM9Hnncnv5Dbeyb7vRV_nWTUfTgIp_lqqbXL0WVenYLJxyfLwofXjeccq9P1_0H1cUrW4orggouWC0YrCR5ROMedk3dNjcCsfMyQPGZLHDMlDhirn3b9TPDH-Job-AcVpx7o</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Aslfalah, Hadise</creator><creator>Jamilian, Mehri</creator><creator>Ansarihadipour, Hadi</creator><creator>Abdollahi, Mahdi</creator><creator>Khosrowbeygi, Ali</creator><general>Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</general><general>Knowledge E</general><general>Shahid Sadoughi University of Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20201201</creationdate><title>Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study</title><author>Aslfalah, Hadise ; Jamilian, Mehri ; Ansarihadipour, Hadi ; Abdollahi, Mahdi ; Khosrowbeygi, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-5efb3f5b5ac64a2196c992c8d1b8db3347bd690f9b594b63d448c373f197be263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cellulose acetate</topic><topic>Cholesterol</topic><topic>Gestational diabetes</topic><topic>Lipids</topic><topic>lipoic acid, gestational diabetes, lipids, triglycerides, cholesterol</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aslfalah, Hadise</creatorcontrib><creatorcontrib>Jamilian, Mehri</creatorcontrib><creatorcontrib>Ansarihadipour, Hadi</creatorcontrib><creatorcontrib>Abdollahi, Mahdi</creatorcontrib><creatorcontrib>Khosrowbeygi, Ali</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International Journal of Reproductive BioMedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aslfalah, Hadise</au><au>Jamilian, Mehri</au><au>Ansarihadipour, Hadi</au><au>Abdollahi, Mahdi</au><au>Khosrowbeygi, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study</atitle><jtitle>International Journal of Reproductive BioMedicine</jtitle><addtitle>Int J Reprod Biomed</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>18</volume><issue>12</issue><spage>1029</spage><epage>1038</epage><pages>1029-1038</pages><issn>2476-4108</issn><eissn>2476-3772</eissn><abstract>Evidence suggests that Oxidative stress has been shown to plays an important role in gestational diabetes mellitus (GDM) etiology. On the other hand, women with GDM are at an increased risk for complications such as endothelial dysfunction and cardiovascular diseases.
To investigate the effects of alpha-lipoic acid (ALA) on the maternal circulating values of lipid profile and lipid ratios in women with GDM.
Sixty women with GDM were participated in the present study. The ALA group (n = 30) received ALA (100 mg/day) and the placebo group (n = 30) received cellulose acetate (100 mg/day) for eight wk. The maternal circulating values of hemoglobin A1C, triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride-glucose (TyG) index, atherogenic index of plasma (AIP), non-HDL-C, and lipid ratios were assessed before and after the intervention. P-value
0.05 was considered as statistically significant.
The values of TyG index (p
0.001), TG (p = 0.006), TG/HDL-C (p = 0.003), and AIP (p = 0.005) decreased significantly in the ALA group after the intervention.
Maternal circulating values of TyG index, TG, TG/HDL, AIP decreased after eight wk of ALA supplementation in women with GDM.</abstract><cop>Iran</cop><pub>Yazd Shahid Sadoughi University of Medical Sciences, Research and Clinical Center for Infertility</pub><pmid>33426413</pmid><doi>10.18502/ijrm.v18i12.8024</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2476-4108 |
| ispartof | International Journal of Reproductive BioMedicine, 2020-12, Vol.18 (12), p.1029-1038 |
| issn | 2476-4108 2476-3772 |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Cellulose acetate Cholesterol Gestational diabetes Lipids lipoic acid, gestational diabetes, lipids, triglycerides, cholesterol Womens health |
| title | Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study |
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