Physical mechanisms of amyloid nucleation on fluid membranes

Biological membranes can dramatically accelerate the aggregation of normally soluble protein molecules into amyloid fibrils and alter the fibril morphologies, yet the molecular mechanisms through which this accelerated nucleation takes place are not yet understood. Here, we develop a coarse-grained...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-12, Vol.117 (52), p.33090-33098
Hauptverfasser:	Krausser, Johannes, Knowles, Tuomas P. J., Šaric, Anđela
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Biological Sciences Cell Membrane - chemistry Computer Simulation Lipid Bilayers - chemistry Membrane Fluidity Membrane Lipids - chemistry Physical Sciences
Online-Zugang:	Volltext
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