IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

The diverse composition of mammalian tissues poses challenges for understanding the cell-cell interactions required for organ homeostasis and how spatial relationships are perturbed during disease. Existing methods such as single-cell genomics, lacking a spatial context, and traditional immunofluore...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-12, Vol.117 (52), p.33455-33465
Hauptverfasser:	Radtke, Andrea J, Kandov, Evelyn, Lowekamp, Bradley, Speranza, Emily, Chu, Colin J, Gola, Anita, Thakur, Nishant, Shih, Rochelle, Yao, Li, Yaniv, Ziv Rafael, Beuschel, Rebecca T, Kabat, Juraj, Croteau, Joshua, Davis, Jeremy, Hernandez, Jonathan M, Germain, Ronald N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cells - metabolism Fluorescent Dyes - metabolism Humans Image Processing, Computer-Assisted Immunization Lymph Nodes - diagnostic imaging Mice Optical Imaging - methods Organ Specificity Phenotype
Online-Zugang:	Volltext
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