In vivo delivery of a multiepitope peptide and Nef protein using novel cell-penetrating peptides for development of HIV-1 vaccine candidate

Objectives A potent HIV vaccine should overcome some limitations such as polymorphism of human HLA, the diversity of HIV-1 virus, and the lack of an effective delivery system. In this study, a DNA construct encoding Nef 60–84 , Nef 126–144 , Vpr 34–47 , Vpr 60–75 , Gp160 30–53 , Gp160 308–323, and P...

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