Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis

Background and Aims In cholestatic liver diseases, ductular reactive (DR) cells extend into the hepatic parenchyma and promote inflammation and fibrosis. We have previously observed that multidrug‐resistant 2 (Mdr2−/−) double knockout (DKO) mice lacking tumor necrosis factor–related apoptosis‐induci...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2020-09, Vol.72 (3), p.1013-1028
Hauptverfasser:	Azad, Adiba I., Krishnan, Anuradha, Troop, Leia, Li, Ying, Katsumi, Tomohiro, Pavelko, Kevin, Kostallari, Enis, Guicciardi, Maria Eugenia, Gores, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects B-Lymphocytes - drug effects B-Lymphocytes - immunology Bile Bile Ducts, Intrahepatic - pathology Bone marrow Bone mass Cell adhesion & migration Cell adhesion molecules Chemokines Cholangitis Cholestasis Cholestasis - drug therapy Cholestasis - metabolism Cholestasis - pathology Cytometry Disease Models, Animal Epithelial Cell Adhesion Molecule - metabolism Epithelial cells Epithelial Cells - drug effects Epithelial Cells - immunology Fibrosis Gallbladder diseases Hepatocytes Hepatology Humans Inflammation Intravenous administration Ligands Liver Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - prevention & control Liver diseases Lymphocytes B Macrophages Mcl-1 protein Mice Mice, Knockout Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors Myeloid Cell Leukemia Sequence 1 Protein - metabolism Parenchyma Phenotypes Pyrimidines - pharmacology Signal Transduction - drug effects Thiophenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!