Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) novel coronavirus 2019 (COVID-19) global pandemic has led to millions of cases and hundreds of thousands of deaths. While older adults appear at high risk for severe disease, hospitalizations and deaths due to SARS-CoV-2 among children...

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Veröffentlicht in:	The Journal of clinical investigation 2021-01, Vol.131 (1), p.1-7
Hauptverfasser:	Schuler, Bryce A, Habermann, A Christian, Plosa, Erin J, Taylor, Chase J, Jetter, Christopher, Negretti, Nicholas M, Kapp, Meghan E, Benjamin, John T, Gulleman, Peter, Nichols, David S, Braunstein, Lior Z, Hackett, Alice, Koval, Michael, Guttentag, Susan H, Blackwell, Timothy S, Webber, Steven A, Banovich, Nicholas E, Kropski, Jonathan A, Sucre, Jennifer Ms
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Age Aging Alveolar Epithelial Cells - enzymology Alveolar Epithelial Cells - pathology Alveolar Epithelial Cells - virology Alveoli Animals Automation Autopsy Biomedical research Care and treatment Child, Preschool Children Concise Communication Control Coronaviridae Coronaviruses COVID-19 COVID-19 - enzymology COVID-19 - metabolism COVID-19 - pathology Development and progression Disease Models, Animal Epidemics Epithelial cells Epithelium Female Gene expression Gene Expression Regulation, Enzymologic Genetic aspects Health aspects Humans Illnesses Immunofluorescence Infant Infants Infections Localization Lungs Male Mice Older people Pandemics Pediatrics Proteases Protein expression Proteins Respiratory tract infections Ribonucleic acid RNA SARS-CoV-2 - metabolism Serine Endopeptidases - biosynthesis Severe acute respiratory syndrome coronavirus 2 Spike protein United States Viral infections
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