Cell-free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer

Physicians are expected to assess prognosis both for patient counseling and for determining suitability for clinical trials. Increasingly, cell-free circulating tumor DNA (cfDNA) sequencing is being performed for clinical decision making. We sought to determine whether variant allele frequency (VAF)...

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Veröffentlicht in:	Clinical cancer research 2020-04, Vol.26 (8), p.1924-1931
Hauptverfasser:	Pairawan, Seyed, Hess, Kenneth R, Janku, Filip, Sanchez, Nora S, Mills Shaw, Kenna R, Eng, Cathy, Damodaran, Senthilkumar, Javle, Milind, Kaseb, Ahmed O, Hong, David S, Subbiah, Vivek, Fu, Siqing, Fogelman, David R, Raymond, Victoria M, Lanman, Richard B, Meric-Bernstam, Funda
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Cell-Free Nucleic Acids - blood Cell-Free Nucleic Acids - genetics Child Female Gene Frequency High-Throughput Nucleotide Sequencing - methods Humans Male Middle Aged Mutation Neoplasm Metastasis Neoplasms - blood Neoplasms - genetics Neoplasms - mortality Neoplasms - pathology Prognosis Retrospective Studies Survival Rate Young Adult
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