Spatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics

In order to analyze how a signal transduction network converts cellular inputs into cellular outputs, ideally one would measure the dynamics of many signals within the network simultaneously. We found that, by fusing a fluorescent reporter to a pair of self-assembling peptides, it could be stably cl...

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Veröffentlicht in:	Cell 2020-12, Vol.183 (6), p.1682-1698.e24
Hauptverfasser:	Linghu, Changyang, Johnson, Shannon L., Valdes, Pablo A., Shemesh, Or A., Park, Won Min, Park, Demian, Piatkevich, Kiryl D., Wassie, Asmamaw T., Liu, Yixi, An, Bobae, Barnes, Stephanie A., Celiker, Orhan T., Yao, Chun-Chen, Yu, Chih-Chieh (Jay), Wang, Ru, Adamala, Katarzyna P., Bear, Mark F., Keating, Amy E., Boyden, Edward S.
Format:	Artikel
Sprache:	eng
Schlagworte:	calcium imaging cAMP fluorescent reporters live-cell imaging protein kinase protein scaffold signal transduction signaling pathway signaling reporter islands spatial multiplexing
Online-Zugang:	Volltext
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