A Mendelian randomization of γ′ and total fibrinogen levels in relation to venous thromboembolism and ischemic stroke

Fibrinogen is a key component of the coagulation cascade, and variation in its circulating levels may contribute to thrombotic diseases, such as venous thromboembolism (VTE) and ischemic stroke. Gamma prime (γ′) fibrinogen is an isoform of fibrinogen that has anticoagulant properties. We applied 2-s...

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Veröffentlicht in:	Blood 2020-12, Vol.136 (26), p.3062-3069
Hauptverfasser:	Maners, Jillian, Gill, Dipender, Pankratz, Nathan, Laffan, Michael A., Wolberg, Alisa S., de Maat, Moniek P.M., Ligthart, Symen, Tang, Weihong, Ward-Caviness, Cavin K., Fornage, Myriam, Debette, Stephanie, Dichgans, Martin, McKnight, Barbara, Boerwinkle, Eric, CHARGE Inflammation Working Group, INVENT Consortium, MEGASTROKE consortium of the International Stroke Genetics Consortium (ISGC), Smith, Nicholas L., Morrison, Alanna C., Dehghan, Abbas, de Vries, Paul S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Fibrinogen - genetics Fibrinogen - metabolism Genetic Variation Genome-Wide Association Study Humans Ischemic Stroke - blood Ischemic Stroke - epidemiology Ischemic Stroke - genetics Male Mendelian Randomization Analysis Risk Factors Thrombosis and Hemostasis Venous Thromboembolism - blood Venous Thromboembolism - epidemiology Venous Thromboembolism - genetics
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