Factors associated with typical enteropathogenic Escherichia coli infection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008–2012
Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children
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| Veröffentlicht in: | Epidemiology and infection 2020-11, Vol.148, p.e281-e281, Article e281 |
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| creator | Fagerli, K. Omore, R. Kim, S. Ochieng, J. B. Ayers, T. L. Juma, J. Farag, T. H. Nasrin, D. Panchalingam, S. Robins-Browne, R. M. Nataro, J. P. Kotloff, K. L. Levine, M. M. Oundo, J. Parsons, M. B. Laserson, K. F. Mintz, E. D. Breiman, R. F. O'Reilly, C. E. |
| description | Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children |
| doi_str_mv | 10.1017/S0950268820002794 |
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B. ; Ayers, T. L. ; Juma, J. ; Farag, T. H. ; Nasrin, D. ; Panchalingam, S. ; Robins-Browne, R. M. ; Nataro, J. P. ; Kotloff, K. L. ; Levine, M. M. ; Oundo, J. ; Parsons, M. B. ; Laserson, K. F. ; Mintz, E. D. ; Breiman, R. F. ; O'Reilly, C. E.</creator><creatorcontrib>Fagerli, K. ; Omore, R. ; Kim, S. ; Ochieng, J. B. ; Ayers, T. L. ; Juma, J. ; Farag, T. H. ; Nasrin, D. ; Panchalingam, S. ; Robins-Browne, R. M. ; Nataro, J. P. ; Kotloff, K. L. ; Levine, M. M. ; Oundo, J. ; Parsons, M. B. ; Laserson, K. F. ; Mintz, E. D. ; Breiman, R. F. ; O'Reilly, C. E.</creatorcontrib><description>Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268820002794</identifier><identifier>PMID: 33190663</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Age ; Case-Control Studies ; Child Nutrition Disorders ; Child, Preschool ; Children ; Children & youth ; Complications ; Confidence intervals ; Convulsions ; Data collection ; Developing countries ; Diarrhea ; Diarrhea - epidemiology ; Diarrhea - microbiology ; Disease control ; E coli ; Enteropathogenic Escherichia coli ; Escherichia coli ; Escherichia coli Infections - epidemiology ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - mortality ; Female ; Health facilities ; Humans ; Infant ; Infant, Newborn ; Infants ; Infections ; Kenya - epidemiology ; LDCs ; Male ; Morbidity ; Mortality ; Original Paper ; Pathogens ; Polymerase chain reaction ; Questionnaires ; Regression analysis ; Rural areas ; Sanitation ; Turgor ; Underweight ; Variables</subject><ispartof>Epidemiology and infection, 2020-11, Vol.148, p.e281-e281, Article e281</ispartof><rights>Copyright © Centers for Disease Control and Prevention 2020. 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B.</creatorcontrib><creatorcontrib>Ayers, T. L.</creatorcontrib><creatorcontrib>Juma, J.</creatorcontrib><creatorcontrib>Farag, T. H.</creatorcontrib><creatorcontrib>Nasrin, D.</creatorcontrib><creatorcontrib>Panchalingam, S.</creatorcontrib><creatorcontrib>Robins-Browne, R. M.</creatorcontrib><creatorcontrib>Nataro, J. P.</creatorcontrib><creatorcontrib>Kotloff, K. L.</creatorcontrib><creatorcontrib>Levine, M. M.</creatorcontrib><creatorcontrib>Oundo, J.</creatorcontrib><creatorcontrib>Parsons, M. B.</creatorcontrib><creatorcontrib>Laserson, K. F.</creatorcontrib><creatorcontrib>Mintz, E. D.</creatorcontrib><creatorcontrib>Breiman, R. F.</creatorcontrib><creatorcontrib>O'Reilly, C. E.</creatorcontrib><title>Factors associated with typical enteropathogenic Escherichia coli infection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008–2012</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.</description><subject>Age</subject><subject>Case-Control Studies</subject><subject>Child Nutrition Disorders</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>Convulsions</subject><subject>Data collection</subject><subject>Developing countries</subject><subject>Diarrhea</subject><subject>Diarrhea - epidemiology</subject><subject>Diarrhea - microbiology</subject><subject>Disease control</subject><subject>E coli</subject><subject>Enteropathogenic Escherichia coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - epidemiology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Infections - mortality</subject><subject>Female</subject><subject>Health facilities</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Kenya - epidemiology</subject><subject>LDCs</subject><subject>Male</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Original Paper</subject><subject>Pathogens</subject><subject>Polymerase chain reaction</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Rural areas</subject><subject>Sanitation</subject><subject>Turgor</subject><subject>Underweight</subject><subject>Variables</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>IKXGN</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1ks2KFDEUhYMoTjv6AG4k4MaFpfmrpAIiyDCj4oALdV2kU7e6MlQlbVI1Q-98B5_Dl_JJvM204x-uEjjnfvee5BLykLNnnHHz_AOzNRO6aQRjTBirbpEVV9pWSjF7m6z2crXXj8i9Ui7QZEVj7pIjKbllWssV-Xbm_Jxyoa6U5IOboaNXYR7ovNsG70YKcYactm4e0gZi8PS0-AFy8ENw1Kcx0BB78HNIkbopxQ1FZewyRPqipjtwyE7jATqlDjL2qOZUFbiEDLQLLuchgUMOzUvGlldQsGek7yDu3FOK4ZrvX74KxsV9cqd3Y4EHh_OYfDo7_Xjypjp___rtyavzyivD50pKqLVlnGvZgzCqButtxxx3SoFQjel7z5lcm7VoHHDUTQceL2tdK247eUxeXnO3y3qCzuMj4GDtNofJ5V2bXGj_VGIY2k26bI0xTBqNgCcHQE6fF8zTTqF4GEcXIS2lFUoza23DDVof_2W9SEuOGG_vqm2tGbfo4tcun1MpGfqbYThr98vQ_rMMWPPo9xQ3FT9_Hw3yAHXTOoduA796_x_7A74RwiY</recordid><startdate>20201116</startdate><enddate>20201116</enddate><creator>Fagerli, K.</creator><creator>Omore, R.</creator><creator>Kim, S.</creator><creator>Ochieng, J. 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Infect</addtitle><date>2020-11-16</date><risdate>2020</risdate><volume>148</volume><spage>e281</spage><epage>e281</epage><pages>e281-e281</pages><artnum>e281</artnum><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33190663</pmid><doi>10.1017/S0950268820002794</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7471-6317</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 2020-11, Vol.148, p.e281-e281, Article e281 |
| issn | 0950-2688 1469-4409 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7770376 |
| source | MEDLINE; Cambridge Journals Open Access; DOAJ Directory of Open Access Journals; PubMed Central |
| subjects | Age Case-Control Studies Child Nutrition Disorders Child, Preschool Children Children & youth Complications Confidence intervals Convulsions Data collection Developing countries Diarrhea Diarrhea - epidemiology Diarrhea - microbiology Disease control E coli Enteropathogenic Escherichia coli Escherichia coli Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Infections - mortality Female Health facilities Humans Infant Infant, Newborn Infants Infections Kenya - epidemiology LDCs Male Morbidity Mortality Original Paper Pathogens Polymerase chain reaction Questionnaires Regression analysis Rural areas Sanitation Turgor Underweight Variables |
| title | Factors associated with typical enteropathogenic Escherichia coli infection among children <5 years old with moderate-to-severe diarrhoea in rural western Kenya, 2008–2012 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T04%3A44%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20associated%20with%20typical%20enteropathogenic%20Escherichia%20coli%20infection%20among%20children%20%3C5%20years%20old%20with%20moderate-to-severe%20diarrhoea%20in%20rural%20western%20Kenya,%202008%E2%80%932012&rft.jtitle=Epidemiology%20and%20infection&rft.au=Fagerli,%20K.&rft.date=2020-11-16&rft.volume=148&rft.spage=e281&rft.epage=e281&rft.pages=e281-e281&rft.artnum=e281&rft.issn=0950-2688&rft.eissn=1469-4409&rft_id=info:doi/10.1017/S0950268820002794&rft_dat=%3Cproquest_pubme%3E2465956019%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2465956019&rft_id=info:pmid/33190663&rft_cupid=10_1017_S0950268820002794&rfr_iscdi=true |