Secondary malignancy risk for patients with localized prostate cancer after intensity‐modulated radiotherapy with and without flattening filter
Men treated for localized prostate cancer by radiotherapy have often a remaining life span of 10 yr or more. Therefore, the risk for secondary malignancies should be taken into account. Plans for ten patients were evaluated which had been performed on an Oncentra® treatment planning system for a tre...
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| Veröffentlicht in: | Journal of applied clinical medical physics 2020-12, Vol.21 (12), p.197-205 |
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| creator | Treutwein, Marius Loeschel, Rainer Hipp, Matthias Koelbl, Oliver Dobler, Barbara |
| description | Men treated for localized prostate cancer by radiotherapy have often a remaining life span of 10 yr or more. Therefore, the risk for secondary malignancies should be taken into account. Plans for ten patients were evaluated which had been performed on an Oncentra® treatment planning system for a treatment with an Elekta Synergy™ linac with Agility™ head. The investigated techniques involved IMRT and VMTA with and without flattening filter. Different dose response models were applied for secondary carcinoma and sarcoma risk in the treated region and also in the periphery. As organs at risk we regarded for carcinoma risk urinary bladder, rectum, colon, esophagus, thyroid, and for sarcoma risk bone and soft tissue. The excess absolute risk (EAR) was found very similar in the treated region for both techniques (IMRT and VMAT) and also for both with and without flattening filter. The secondary sarcoma risk resulted about one magnitude smaller than the secondary carcinoma risk. The EAR to the peripheral organs was statistically significant reduced by application of the flattening filter free mode concerning the flattening filter as main source of scattered dose. Application of flattening filter free mode can thus support to reduce second malignancy risk for patients with localized prostate cancer. |
| doi_str_mv | 10.1002/acm2.13088 |
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Therefore, the risk for secondary malignancies should be taken into account. Plans for ten patients were evaluated which had been performed on an Oncentra® treatment planning system for a treatment with an Elekta Synergy™ linac with Agility™ head. The investigated techniques involved IMRT and VMTA with and without flattening filter. Different dose response models were applied for secondary carcinoma and sarcoma risk in the treated region and also in the periphery. As organs at risk we regarded for carcinoma risk urinary bladder, rectum, colon, esophagus, thyroid, and for sarcoma risk bone and soft tissue. The excess absolute risk (EAR) was found very similar in the treated region for both techniques (IMRT and VMAT) and also for both with and without flattening filter. The secondary sarcoma risk resulted about one magnitude smaller than the secondary carcinoma risk. The EAR to the peripheral organs was statistically significant reduced by application of the flattening filter free mode concerning the flattening filter as main source of scattered dose. Application of flattening filter free mode can thus support to reduce second malignancy risk for patients with localized prostate cancer.</description><identifier>ISSN: 1526-9914</identifier><identifier>EISSN: 1526-9914</identifier><identifier>DOI: 10.1002/acm2.13088</identifier><identifier>PMID: 33147377</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Age ; Bladder ; Cancer therapies ; flattening filter free ; IMRT ; localized prostate cancer ; Prostate cancer ; Radiation Oncology Physics ; Radiation therapy ; secondary malignancy risk ; Thyroid gland ; VMAT</subject><ispartof>Journal of applied clinical medical physics, 2020-12, Vol.21 (12), p.197-205</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.</rights><rights>2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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The EAR to the peripheral organs was statistically significant reduced by application of the flattening filter free mode concerning the flattening filter as main source of scattered dose. Application of flattening filter free mode can thus support to reduce second malignancy risk for patients with localized prostate cancer.</description><subject>Age</subject><subject>Bladder</subject><subject>Cancer therapies</subject><subject>flattening filter free</subject><subject>IMRT</subject><subject>localized prostate cancer</subject><subject>Prostate cancer</subject><subject>Radiation Oncology Physics</subject><subject>Radiation therapy</subject><subject>secondary malignancy risk</subject><subject>Thyroid gland</subject><subject>VMAT</subject><issn>1526-9914</issn><issn>1526-9914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kcFuFSEUhidGY2t14wMYEjfG5FYOzACzMWlutJrUuFDXhAvMvdQZGIFpM658BPuKPoncTm2qCzdwEj6-nHP-qnoK-BgwJq-UHsgxUCzEveoQGsJWbQv1_Tv1QfUopXOMAQQVD6sDSqHmlPPD6uqT1cEbFWc0qN5tvfJ6RtGlr6gLEY0qO-tzQpcu71AfdGG-W4PGGFJW2SJdeBuR6nI5nc_WJ5fnXz9-DsFMfSEMisq4kHc2qnFePMqb6yJMGXUFKr-c36LO9cXyuHrQqT7ZJzf3UfXl7ZvP63ers4-n79cnZytdcyZWNWs5U7WwxtLOKqVJR2yH8QYagEYLLRqKyYYBBayZNUIYMBvWKSY4AFH0qHq9eMdpM1ijy5hR9XKMbijbkEE5-feLdzu5DReSc9bSti2CFzeCGL5NNmU5uKRt3ytvw5QkqRvecswACvr8H_Q8TNGX8QrFKWkwo3vhy4XSZbsp2u62GcByn7TcJy2vky7ws7vt36J_oi0ALMCl6-38H5U8WX8gi_Q30CW48g</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Treutwein, Marius</creator><creator>Loeschel, Rainer</creator><creator>Hipp, Matthias</creator><creator>Koelbl, Oliver</creator><creator>Dobler, Barbara</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6538-9980</orcidid></search><sort><creationdate>202012</creationdate><title>Secondary malignancy risk for patients with localized prostate cancer after intensity‐modulated radiotherapy with and without flattening filter</title><author>Treutwein, Marius ; 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| source | DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library Open Access; PubMed Central |
| subjects | Age Bladder Cancer therapies flattening filter free IMRT localized prostate cancer Prostate cancer Radiation Oncology Physics Radiation therapy secondary malignancy risk Thyroid gland VMAT |
| title | Secondary malignancy risk for patients with localized prostate cancer after intensity‐modulated radiotherapy with and without flattening filter |
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