Multivascular networks and functional intravascular topologies within biocompatible hydrogels
Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopol...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2019-05, Vol.364 (6439), p.458-464 |
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| creator | Grigoryan, Bagrat Paulsen, Samantha J. Corbett, Daniel C. Sazer, Daniel W. Fortin, Chelsea L. Zaita, Alexander J. Greenfield, Paul T. Calafat, Nicholas J. Gounley, John P. Ta, Anderson H. Johansson, Fredrik Randles, Amanda Rosenkrantz, Jessica E. Louis-Rosenberg, Jesse D. Galie, Peter A. Stevens, Kelly R. Miller, Jordan S. |
| description | Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation. |
| doi_str_mv | 10.1126/science.aav9750 |
| format | Article |
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We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2019-05, Vol.364 (6439), p.458-464 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7769170 |
| source | American Association for the Advancement of Science; MEDLINE |
| subjects | Absorption, Physicochemical Additives Animals BASIC BIOLOGICAL SCIENCES Biocompatibility Biocompatible Materials - chemistry Biodegradability Biodegradation Biomimetic Materials - chemistry Blood Vessels Coloring Agents - chemistry Computational fluid dynamics Disease Models, Animal Distension Erythrocytes Erythrocytes - metabolism Food additives Food dyes Humans Hydrogels Hydrogels - chemistry Light Lithography Liver Lung Injury - therapy Mice Mice, Nude Networks Nutrient transport Organs Oxygenation Polymerization - radiation effects Respiratory tract Stereolithography Topology Transport Valves Ventilation Vertebrates |
| title | Multivascular networks and functional intravascular topologies within biocompatible hydrogels |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T18%3A28%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multivascular%20networks%20and%20functional%20intravascular%20topologies%20within%20biocompatible%20hydrogels&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Grigoryan,%20Bagrat&rft.aucorp=Oak%20Ridge%20National%20Laboratory%20(ORNL),%20Oak%20Ridge,%20TN%20(United%20States)&rft.date=2019-05-03&rft.volume=364&rft.issue=6439&rft.spage=458&rft.epage=464&rft.pages=458-464&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.aav9750&rft_dat=%3Cjstor_pubme%3E26649379%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2219020262&rft_id=info:pmid/31048486&rft_jstor_id=26649379&rfr_iscdi=true |