Direct lysosome-based autophagy of lipid droplets in hepatocytes

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelleselective form of this process (macrolipophagy) results in the engulfment of LDs within double-membrane delimited structures (autophagosomes) before lysosomal fusion. Whethe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-12, Vol.117 (51), p.32443-32452
Hauptverfasser:	Schulze, Ryan J., Krueger, Eugene W., Weller, Shaun G., Johnson, Katherine M., Casey, Carol A., Schott, Micah B., McNiven, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagosomes - metabolism Autophagy Autophagy - physiology Biological Sciences Catabolism Cell Line Cell lines Droplets Electron microscopy Extrusion Fluorescence Hepatocytes Hepatocytes - metabolism Homeostasis Lipid Droplets - metabolism Lipid Metabolism Lipids Lysosomes Lysosomes - metabolism Mammalian cells Mammals Membranes Mice Microscopy Microscopy, Confocal Phagocytosis Phagosomes Protein Transport Proteins Rats, Sprague-Dawley
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