Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults
Abstract Objectives To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time. Methods Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy d...
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| Veröffentlicht in: | The journals of gerontology. Series B, Psychological sciences and social sciences Psychological sciences and social sciences, 2020-02, Vol.75 (3), p.577-584 |
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| container_title | The journals of gerontology. Series B, Psychological sciences and social sciences |
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| creator | Knight, Jamie E Bennett, David A Piccinin, Andrea M |
| description | Abstract
Objectives
To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.
Methods
Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.
Results
Individuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.
Discussion
BSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology. |
| doi_str_mv | 10.1093/geronb/gby058 |
| format | Article |
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Objectives
To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.
Methods
Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.
Results
Individuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.
Discussion
BSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.</description><identifier>ISSN: 1079-5014</identifier><identifier>EISSN: 1758-5368</identifier><identifier>DOI: 10.1093/geronb/gby058</identifier><identifier>PMID: 29762752</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - physiopathology ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Memory Disorders - diagnosis ; Memory Disorders - physiopathology ; Memory, Episodic ; Middle Aged ; Olfaction Disorders - diagnosis ; Olfaction Disorders - physiopathology ; The Journal of Gerontology: Psychological Sciences</subject><ispartof>The journals of gerontology. Series B, Psychological sciences and social sciences, 2020-02, Vol.75 (3), p.577-584</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-1faf7f68e76e1e4f9a130b0184e248eecfd0c506704c3325ddf4c3a23ee613833</citedby><cites>FETCH-LOGICAL-c420t-1faf7f68e76e1e4f9a130b0184e248eecfd0c506704c3325ddf4c3a23ee613833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29762752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Anderson, Nicole D</contributor><creatorcontrib>Knight, Jamie E</creatorcontrib><creatorcontrib>Bennett, David A</creatorcontrib><creatorcontrib>Piccinin, Andrea M</creatorcontrib><title>Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults</title><title>The journals of gerontology. Series B, Psychological sciences and social sciences</title><addtitle>J Gerontol B Psychol Sci Soc Sci</addtitle><description>Abstract
Objectives
To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.
Methods
Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.
Results
Individuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.
Discussion
BSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Memory Disorders - diagnosis</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory, Episodic</subject><subject>Middle Aged</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfaction Disorders - physiopathology</subject><subject>The Journal of Gerontology: Psychological Sciences</subject><issn>1079-5014</issn><issn>1758-5368</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LxDAQxYMofh-9So9eqvlom_YiyLLqgrIXFW8hTSY10m3WpBX2vzfaddWTc5mB-fHmMQ-hE4LPCa7YRQPedfVFU69wXm6hfcLzMs1ZUW7HGfMqzTHJ9tBBCK84FuHZLtqjFS8oz-k-en6S3sratrZfJbLTycQNy9Z2TeJMMm-NVL3zq2SmoeutsUr21nVf4HRpg9NWJfew-ERsF3kNPrnSQ9uHI7RjZBvgeN0P0eP19GFym97Nb2aTq7tUZRT3KTHScFOUwAsgkJlKEoZrTMoMaFYCKKOxynHBcaYYo7nWJg6SMoCCsJKxQ3Q56i6HegFaRZ9etmLp7UL6lXDSir-bzr6Ixr0LzouSExoFztYC3r0NEHqxsEFB28oO3BAExayiFSN5FtF0RJV3IXgwmzMEi880xJiGGNOI_Olvbxv6-_0_t-PT_9H6AL0Jl50</recordid><startdate>20200214</startdate><enddate>20200214</enddate><creator>Knight, Jamie E</creator><creator>Bennett, David A</creator><creator>Piccinin, Andrea M</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200214</creationdate><title>Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults</title><author>Knight, Jamie E ; Bennett, David A ; Piccinin, Andrea M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-1faf7f68e76e1e4f9a130b0184e248eecfd0c506704c3325ddf4c3a23ee613833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Memory Disorders - diagnosis</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory, Episodic</topic><topic>Middle Aged</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfaction Disorders - physiopathology</topic><topic>The Journal of Gerontology: Psychological Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knight, Jamie E</creatorcontrib><creatorcontrib>Bennett, David A</creatorcontrib><creatorcontrib>Piccinin, Andrea M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journals of gerontology. Series B, Psychological sciences and social sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knight, Jamie E</au><au>Bennett, David A</au><au>Piccinin, Andrea M</au><au>Anderson, Nicole D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults</atitle><jtitle>The journals of gerontology. Series B, Psychological sciences and social sciences</jtitle><addtitle>J Gerontol B Psychol Sci Soc Sci</addtitle><date>2020-02-14</date><risdate>2020</risdate><volume>75</volume><issue>3</issue><spage>577</spage><epage>584</epage><pages>577-584</pages><issn>1079-5014</issn><eissn>1758-5368</eissn><abstract>Abstract
Objectives
To determine whether assessment-to-assessment fluctuations in episodic memory (EM) reflect fluctuations in olfaction over time.
Methods
Within-person coupled variation in EM and the Brief Smell Identification Test (BSIT) was examined in 565 participants aged 58–106 with autopsy data from the Rush Memory and Aging Project. A growth model for up to 15 years of EM data, with BSIT as time-varying covariate, was estimated accounting for main effects of sex, education, ε4 allele, and Alzheimer’s disease (AD) pathology, BSIT and time-varying BSIT, as well as the interaction between AD pathology and time-varying BSIT.
Results
Individuals with higher BSIT scores (b = .01, standard error [SE] = .004, p = .009) had slower declines in EM. High AD pathology (b = −.06, SE = .02, p = .001) was associated with more rapid declines in EM. The association between time-specific fluctuations in EM and BSIT differed by level of AD pathology (b = .08, SE = .034, p = .028), with a higher EM–BSIT association at higher levels of pathology.
Discussion
BSIT and EM fluctuate together over measurement occasions, particularly for individuals with AD pathology. Repeated intraindividual measurements provide information that could lead to early detection and inexpensive monitoring of accumulating AD pathology.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29762752</pmid><doi>10.1093/geronb/gby058</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - pathology Alzheimer Disease - physiopathology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - physiopathology Disease Progression Female Humans Longitudinal Studies Male Memory Disorders - diagnosis Memory Disorders - physiopathology Memory, Episodic Middle Aged Olfaction Disorders - diagnosis Olfaction Disorders - physiopathology The Journal of Gerontology: Psychological Sciences |
| title | Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults |
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