Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events
There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-...
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| Veröffentlicht in: | International journal of molecular sciences 2020-12, Vol.21 (24), p.9600 |
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| description | There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs (
= 35) and with CVEs (
= 12), during 1 year follow-up. Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of
and
were determined. Results showed that, in the plaques, miR-142, miR-223, and miR-155 expression levels were significantly increased in PAD patients with CVEs compared to those without CVEs. Positive correlations between these miRNAs and their pri-miRNAs levels and the
expression were observed. In the plasma of PAD patients with CVEs compared to those without CVEs, miR-223 and miR-142 were significantly increased. The multiple linear regression analyses revealed significant associations among several plasma lipids, oxidative and inflammatory parameters, and plasma miRNAs levels. Receiver operator characteristic (ROC) analysis disclosed that plasma miR-142 levels could be an independent predictor for CVEs in PAD patients. Functional bioinformatics analyses supported the role of these miRNAs in the regulation of biological processes associated with atherosclerosis. Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients. |
| doi_str_mv | 10.3390/ijms21249600 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7766790</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471466445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-83175fdf723184cfc2407cf70db56135a3f50f6048986394b3e855bb0092e19a3</originalsourceid><addsrcrecordid>eNpdkUuPFCEUhYnROOPozrUhcePCUt4UG5NOO-okndjxsSYUBdN0qooWqDbzJ_zNUs44aWUBJOfjcM-9ADzH6A2lCr0N-zETTJgSCD0A55gR0iAk5MOT-xl4kvMeIUIJV4_BGa1LMazOwa-rySZnsuvhGL409QXcuKMbMgwT3A4mjwaaqYersnMpZjvUvQS7SD9ml6FPcYRbl8Kh6maAq1RcuoHvQ15M4daU4KaS4c9QdnAbc2m-zul6QdYm9SEeTbbzYBK8PC7cU_DImyG7Z3fnBfj-4fLb-lOz-fzxar3aNJZhUpqWYsl97yWhuGXWW8KQtF6ivuMCU26o58gLxFrVipq0o67lvOsQUsRhZegFeHfre5i70fW2_l2r14cURpNudDRB_6tMYaev41FLKYRUqBq8ujNIcWlE0WPI1g2DmVycsyZMYiYEY7yiL_9D93FOU433h-ItQngxfH1L2drmnJy_LwYjvQxanw664i9OA9zDfydLfwNhiKWJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471580010</pqid></control><display><type>article</type><title>Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Barbalata, Teodora ; Moraru, Oriana E ; Stancu, Camelia S ; Devaux, Yvan ; Simionescu, Maya ; Sima, Anca V ; Niculescu, Loredan S</creator><creatorcontrib>Barbalata, Teodora ; Moraru, Oriana E ; Stancu, Camelia S ; Devaux, Yvan ; Simionescu, Maya ; Sima, Anca V ; Niculescu, Loredan S</creatorcontrib><description>There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs (
= 35) and with CVEs (
= 12), during 1 year follow-up. Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of
and
were determined. Results showed that, in the plaques, miR-142, miR-223, and miR-155 expression levels were significantly increased in PAD patients with CVEs compared to those without CVEs. Positive correlations between these miRNAs and their pri-miRNAs levels and the
expression were observed. In the plasma of PAD patients with CVEs compared to those without CVEs, miR-223 and miR-142 were significantly increased. The multiple linear regression analyses revealed significant associations among several plasma lipids, oxidative and inflammatory parameters, and plasma miRNAs levels. Receiver operator characteristic (ROC) analysis disclosed that plasma miR-142 levels could be an independent predictor for CVEs in PAD patients. Functional bioinformatics analyses supported the role of these miRNAs in the regulation of biological processes associated with atherosclerosis. Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21249600</identifier><identifier>PMID: 33339419</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Amputation ; Arteriosclerosis ; Atherosclerosis ; Bioinformatics ; Biological activity ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Cholesterol ; Enzymes ; Female ; Femoral artery ; Femoral Artery - surgery ; Femur ; Gene expression ; Heart attacks ; Humans ; Inflammation ; Lipids ; Male ; Metabolism ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - metabolism ; Middle Aged ; miRNA ; Peripheral Arterial Disease - blood ; Peripheral Arterial Disease - metabolism ; Peripheral Arterial Disease - surgery ; Plaque, Atherosclerotic - blood ; Plaque, Atherosclerotic - metabolism ; Plaques ; Plasma ; Plasma levels ; Postoperative Complications - blood ; Postoperative Complications - metabolism ; Regression analysis ; Surgery ; Vascular diseases ; Vascular Grafting - adverse effects</subject><ispartof>International journal of molecular sciences, 2020-12, Vol.21 (24), p.9600</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-83175fdf723184cfc2407cf70db56135a3f50f6048986394b3e855bb0092e19a3</citedby><cites>FETCH-LOGICAL-c412t-83175fdf723184cfc2407cf70db56135a3f50f6048986394b3e855bb0092e19a3</cites><orcidid>0000-0002-1394-9085 ; 0000-0002-5321-8543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766790/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766790/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33339419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbalata, Teodora</creatorcontrib><creatorcontrib>Moraru, Oriana E</creatorcontrib><creatorcontrib>Stancu, Camelia S</creatorcontrib><creatorcontrib>Devaux, Yvan</creatorcontrib><creatorcontrib>Simionescu, Maya</creatorcontrib><creatorcontrib>Sima, Anca V</creatorcontrib><creatorcontrib>Niculescu, Loredan S</creatorcontrib><title>Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs (
= 35) and with CVEs (
= 12), during 1 year follow-up. Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of
and
were determined. Results showed that, in the plaques, miR-142, miR-223, and miR-155 expression levels were significantly increased in PAD patients with CVEs compared to those without CVEs. Positive correlations between these miRNAs and their pri-miRNAs levels and the
expression were observed. In the plasma of PAD patients with CVEs compared to those without CVEs, miR-223 and miR-142 were significantly increased. The multiple linear regression analyses revealed significant associations among several plasma lipids, oxidative and inflammatory parameters, and plasma miRNAs levels. Receiver operator characteristic (ROC) analysis disclosed that plasma miR-142 levels could be an independent predictor for CVEs in PAD patients. Functional bioinformatics analyses supported the role of these miRNAs in the regulation of biological processes associated with atherosclerosis. Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amputation</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Bioinformatics</subject><subject>Biological activity</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Enzymes</subject><subject>Female</subject><subject>Femoral artery</subject><subject>Femoral Artery - surgery</subject><subject>Femur</subject><subject>Gene expression</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipids</subject><subject>Male</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Peripheral Arterial Disease - blood</subject><subject>Peripheral Arterial Disease - metabolism</subject><subject>Peripheral Arterial Disease - surgery</subject><subject>Plaque, Atherosclerotic - blood</subject><subject>Plaque, Atherosclerotic - metabolism</subject><subject>Plaques</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - metabolism</subject><subject>Regression analysis</subject><subject>Surgery</subject><subject>Vascular diseases</subject><subject>Vascular Grafting - adverse effects</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUuPFCEUhYnROOPozrUhcePCUt4UG5NOO-okndjxsSYUBdN0qooWqDbzJ_zNUs44aWUBJOfjcM-9ADzH6A2lCr0N-zETTJgSCD0A55gR0iAk5MOT-xl4kvMeIUIJV4_BGa1LMazOwa-rySZnsuvhGL409QXcuKMbMgwT3A4mjwaaqYersnMpZjvUvQS7SD9ml6FPcYRbl8Kh6maAq1RcuoHvQ15M4daU4KaS4c9QdnAbc2m-zul6QdYm9SEeTbbzYBK8PC7cU_DImyG7Z3fnBfj-4fLb-lOz-fzxar3aNJZhUpqWYsl97yWhuGXWW8KQtF6ivuMCU26o58gLxFrVipq0o67lvOsQUsRhZegFeHfre5i70fW2_l2r14cURpNudDRB_6tMYaev41FLKYRUqBq8ujNIcWlE0WPI1g2DmVycsyZMYiYEY7yiL_9D93FOU433h-ItQngxfH1L2drmnJy_LwYjvQxanw664i9OA9zDfydLfwNhiKWJ</recordid><startdate>20201216</startdate><enddate>20201216</enddate><creator>Barbalata, Teodora</creator><creator>Moraru, Oriana E</creator><creator>Stancu, Camelia S</creator><creator>Devaux, Yvan</creator><creator>Simionescu, Maya</creator><creator>Sima, Anca V</creator><creator>Niculescu, Loredan S</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1394-9085</orcidid><orcidid>https://orcid.org/0000-0002-5321-8543</orcidid></search><sort><creationdate>20201216</creationdate><title>Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events</title><author>Barbalata, Teodora ; Moraru, Oriana E ; Stancu, Camelia S ; Devaux, Yvan ; Simionescu, Maya ; Sima, Anca V ; Niculescu, Loredan S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-83175fdf723184cfc2407cf70db56135a3f50f6048986394b3e855bb0092e19a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amputation</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Bioinformatics</topic><topic>Biological activity</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Enzymes</topic><topic>Female</topic><topic>Femoral artery</topic><topic>Femoral Artery - surgery</topic><topic>Femur</topic><topic>Gene expression</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lipids</topic><topic>Male</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Peripheral Arterial Disease - blood</topic><topic>Peripheral Arterial Disease - metabolism</topic><topic>Peripheral Arterial Disease - surgery</topic><topic>Plaque, Atherosclerotic - blood</topic><topic>Plaque, Atherosclerotic - metabolism</topic><topic>Plaques</topic><topic>Plasma</topic><topic>Plasma levels</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - metabolism</topic><topic>Regression analysis</topic><topic>Surgery</topic><topic>Vascular diseases</topic><topic>Vascular Grafting - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbalata, Teodora</creatorcontrib><creatorcontrib>Moraru, Oriana E</creatorcontrib><creatorcontrib>Stancu, Camelia S</creatorcontrib><creatorcontrib>Devaux, Yvan</creatorcontrib><creatorcontrib>Simionescu, Maya</creatorcontrib><creatorcontrib>Sima, Anca V</creatorcontrib><creatorcontrib>Niculescu, Loredan S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbalata, Teodora</au><au>Moraru, Oriana E</au><au>Stancu, Camelia S</au><au>Devaux, Yvan</au><au>Simionescu, Maya</au><au>Sima, Anca V</au><au>Niculescu, Loredan S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-12-16</date><risdate>2020</risdate><volume>21</volume><issue>24</issue><spage>9600</spage><pages>9600-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs (
= 35) and with CVEs (
= 12), during 1 year follow-up. Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of
and
were determined. Results showed that, in the plaques, miR-142, miR-223, and miR-155 expression levels were significantly increased in PAD patients with CVEs compared to those without CVEs. Positive correlations between these miRNAs and their pri-miRNAs levels and the
expression were observed. In the plasma of PAD patients with CVEs compared to those without CVEs, miR-223 and miR-142 were significantly increased. The multiple linear regression analyses revealed significant associations among several plasma lipids, oxidative and inflammatory parameters, and plasma miRNAs levels. Receiver operator characteristic (ROC) analysis disclosed that plasma miR-142 levels could be an independent predictor for CVEs in PAD patients. Functional bioinformatics analyses supported the role of these miRNAs in the regulation of biological processes associated with atherosclerosis. Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33339419</pmid><doi>10.3390/ijms21249600</doi><orcidid>https://orcid.org/0000-0002-1394-9085</orcidid><orcidid>https://orcid.org/0000-0002-5321-8543</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Amputation Arteriosclerosis Atherosclerosis Bioinformatics Biological activity Biomarkers Biomarkers - blood Biomarkers - metabolism Cardiovascular disease Cardiovascular diseases Cholesterol Enzymes Female Femoral artery Femoral Artery - surgery Femur Gene expression Heart attacks Humans Inflammation Lipids Male Metabolism MicroRNAs MicroRNAs - blood MicroRNAs - metabolism Middle Aged miRNA Peripheral Arterial Disease - blood Peripheral Arterial Disease - metabolism Peripheral Arterial Disease - surgery Plaque, Atherosclerotic - blood Plaque, Atherosclerotic - metabolism Plaques Plasma Plasma levels Postoperative Complications - blood Postoperative Complications - metabolism Regression analysis Surgery Vascular diseases Vascular Grafting - adverse effects |
| title | Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events |
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