Oral Administration of Salecan-Based Hydrogels for Controlled Insulin Delivery

We present an improved type of food gum (salecan) based hydrogels for oral delivery of insulin. Structural hydrogel formation was assessed with Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction. We found that the hydrogel modulus, morphology, and swelling pro...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2018-10, Vol.66 (40), p.10479-10489
Hauptverfasser:	Qi, Xiaoliang, Yuan, Yue, Zhang, Jianfa, Bulte, Jeff W. M, Dong, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals beta-Glucans - chemistry Cell Survival - drug effects Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Diabetes Mellitus, Experimental Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Excipients Humans Hydrogels - chemistry Hydrogen-Ion Concentration Insulin - administration & dosage Insulin - chemistry Rats Rats, Wistar Spectroscopy, Fourier Transform Infrared Thermogravimetry
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