Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, the unique signature of early immune responses remains elusive. We characterized the...

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Veröffentlicht in:	Cell host & microbe 2021-02, Vol.29 (2), p.222-235.e4
Hauptverfasser:	Guo, Qirui, Zhao, Yingchi, Li, Junhong, Liu, Jiangning, Yang, Xiuhong, Guo, Xuefei, Kuang, Ming, Xia, Huawei, Zhang, Zeming, Cao, Lili, Luo, Yujie, Bao, Linlin, Wang, Xiao, Wei, Xuemei, Deng, Wei, Wang, Nan, Chen, Luoying, Chen, Jingxuan, Zhu, Hua, Gao, Ran, Qin, Chuan, Wang, Xiangxi, You, Fuping
Format:	Artikel
Sprache:	eng
Schlagworte:	aberrant neutrophils Alarmins - pharmacology Animals Antiviral Agents - pharmacology COVID-19 - metabolism COVID-19 - virology COVID-19 Drug Treatment Disease Models, Animal Female Humans Macaca mulatta Male Mice Mice, Inbred C57BL Mice, Knockout Neutrophils - drug effects Neutrophils - metabolism Paquinimod S100A8/A9 SARS-CoV-2 SARS-CoV-2 - drug effects Transcriptome Viral Load
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