S100A10 Has a Critical Regulatory Function in Mammary Tumor Growth and Metastasis: Insights Using MMTV-PyMT Oncomice and Clinical Patient Sample Analysis

S100A10 (p11) is a plasminogen receptor that regulates cellular plasmin generation by cancer cells. In the current study, we used the MMTV-PyMT mouse breast cancer model, patient tumor microarray, and immunohistochemical (IHC) analysis to investigate the role of p11 in oncogenesis. The genetic delet...

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Veröffentlicht in:	Cancers 2020-12, Vol.12 (12), p.3673
Hauptverfasser:	Bharadwaj, Alamelu G, Dahn, Margaret L, Liu, Rong-Zong, Colp, Patricia, Thomas, Lynn N, Holloway, Ryan W, Marignani, Paola A, Too, Catherine Kl, Barnes, Penelope J, Godbout, Rosaline, Marcato, Paola, Waisman, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Breast cancer Calcium-binding protein Cell growth DNA microarrays Fibrosarcoma Gene expression Growth rate Inflammation Interferon Interleukin 10 Invasiveness Lung carcinoma Lungs Macrophages Mammary gland Medical prognosis Metastases Metastasis Phenotypes Plasmin Rodents S100 protein Tumor cells Tumorigenesis Tumors
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