Update on the Management of Breast Cancer during Pregnancy
The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is need...
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| Veröffentlicht in: | Cancers 2020-12, Vol.12 (12), p.3616 |
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| container_title | Cancers |
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| creator | Poggio, Francesca Tagliamento, Marco Pirrone, Chiara Soldato, Davide Conte, Benedetta Molinelli, Chiara Cosso, Maurizio Fregatti, Piero Del Mastro, Lucia Lambertini, Matteo |
| description | The diagnosis of breast cancer during pregnancy represents a challenging situation for the patient, her caregivers and physicians. Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy. |
| doi_str_mv | 10.3390/cancers12123616 |
| format | Article |
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Pregnancy adds complexity to oncological treatment planning, as many therapies can be potentially dangerous to the fetus. Therefore, a multidisciplinary approach is needed to offer a proper care for obtaining the best possible outcomes for the mother and the future child. Breast surgery is feasible throughout the pregnancy while radiotherapy should be postponed after delivery. Administration of chemotherapy is considered safe and can be given during the second and third trimesters, while it is contraindicated in the first trimester due to the high risk of fetal malformations. Endocrine therapy and targeted agents are not recommended during the whole pregnancy period; however, limited data are available on the use of the majority of new anticancer drugs in this context. The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers12123616</identifier><identifier>PMID: 33287242</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antitumor agents ; Biology ; Biopsy ; Breast cancer ; Cancer therapies ; Chemotherapy ; Contraindications ; Cytotoxicity ; Drug dosages ; Endocrine therapy ; Fetuses ; Genomes ; Gestational age ; Lymphatic system ; Medical prognosis ; Mutation ; Patients ; Pregnancy ; Radiation therapy ; Review ; Surgery ; Womens health</subject><ispartof>Cancers, 2020-12, Vol.12 (12), p.3616</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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The aim of the current review is to provide an update on the current state of art about the management of women diagnosed with breast cancer during pregnancy.</description><subject>Antitumor agents</subject><subject>Biology</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Contraindications</subject><subject>Cytotoxicity</subject><subject>Drug dosages</subject><subject>Endocrine therapy</subject><subject>Fetuses</subject><subject>Genomes</subject><subject>Gestational age</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Mutation</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Surgery</subject><subject>Womens health</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkTtPwzAUhS0EolXpzIYisbCE-pU4YUCCipdUBAOdLce5SVMlTrETpP57XFpQqZdr2d8993EQOif4mrEUT7QyGqwjlFAWk_gIDSkWNIzjlB_v3Qdo7NwS-8MYEbE4RQPGaCIop0N0M1_lqoOgNUG3gOBVGVVCA6YL2iK4t6BcF0x_6gR5bytTBu8WSuNf1mfopFC1g_EujtD88eFj-hzO3p5epnezUPNEdKHIRaaTlGkgUPAE4yTThcg1jniUaS4oqAKnTNA8jRKiNOGkAMYLDllEYpqxEbrd6q76rIFc--asquXKVo2ya9mqSv7_MdVClu2XFMJvJUq9wNVOwLafPbhONpXTUNfKQNs7SXmc-NUwGnn08gBdtr01frwNJdKEEYo9NdlS2rbOWSj-miFYbqyRB9b4jIv9Gf74XyPYN_nlio8</recordid><startdate>20201203</startdate><enddate>20201203</enddate><creator>Poggio, Francesca</creator><creator>Tagliamento, Marco</creator><creator>Pirrone, Chiara</creator><creator>Soldato, Davide</creator><creator>Conte, Benedetta</creator><creator>Molinelli, Chiara</creator><creator>Cosso, Maurizio</creator><creator>Fregatti, Piero</creator><creator>Del Mastro, Lucia</creator><creator>Lambertini, Matteo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1797-5296</orcidid><orcidid>https://orcid.org/0000-0002-9546-5841</orcidid><orcidid>https://orcid.org/0000-0001-7461-023X</orcidid></search><sort><creationdate>20201203</creationdate><title>Update on the Management of Breast Cancer during Pregnancy</title><author>Poggio, Francesca ; 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| subjects | Antitumor agents Biology Biopsy Breast cancer Cancer therapies Chemotherapy Contraindications Cytotoxicity Drug dosages Endocrine therapy Fetuses Genomes Gestational age Lymphatic system Medical prognosis Mutation Patients Pregnancy Radiation therapy Review Surgery Womens health |
| title | Update on the Management of Breast Cancer during Pregnancy |
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