Factors Associated with the Prescribing of High-Intensity Statins
In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Stati...
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| Veröffentlicht in: | Journal of clinical medicine 2020-11, Vol.9 (12), p.3850 |
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| container_title | Journal of clinical medicine |
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| creator | Chaure-Pardos, Armando Malo, Sara Rabanaque, María José Arribas, Federico Moreno-Franco, Belén Aguilar-Palacio, Isabel |
| description | In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as "high-intensity" or "low-moderate-intensity". Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus |
| doi_str_mv | 10.3390/jcm9123850 |
| format | Article |
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We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as "high-intensity" or "low-moderate-intensity". Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus <20 METs (metabolic equivalent of task) h/wk; odds ratio (OR), 1.65; 95%CI, 1.08-2.50) and, in diabetics, higher low-density lipoprotein cholesterol (LDL-C) levels (≥155 mg/dL versus <155 mg/dL; OR, 4.96; 95%CI, 1.29-19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574-0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in diabetics with high LDL-C levels and in more physically active individuals. These findings underscore the great variability and uncertainty in the prescribing of statins.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9123850</identifier><identifier>PMID: 33260835</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antihypertensives ; Atherosclerosis ; Blood pressure ; Cholesterol ; Classification ; Clinical medicine ; Codes ; Diabetes ; Diet ; Disease prevention ; Drug dosages ; Lifestyles ; Lipids ; Lipoproteins ; Prescription drugs ; Primary care ; Questionnaires ; Shift work ; Sleep ; Statins ; Workers</subject><ispartof>Journal of clinical medicine, 2020-11, Vol.9 (12), p.3850</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-471a15231715625e087e95c4fc5119e532492f97d368e8b0248ffc36736d35063</citedby><cites>FETCH-LOGICAL-c406t-471a15231715625e087e95c4fc5119e532492f97d368e8b0248ffc36736d35063</cites><orcidid>0000-0001-7293-701X ; 0000-0002-7194-8275 ; 0000-0002-6671-5661</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760403/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760403/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33260835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaure-Pardos, Armando</creatorcontrib><creatorcontrib>Malo, Sara</creatorcontrib><creatorcontrib>Rabanaque, María José</creatorcontrib><creatorcontrib>Arribas, Federico</creatorcontrib><creatorcontrib>Moreno-Franco, Belén</creatorcontrib><creatorcontrib>Aguilar-Palacio, Isabel</creatorcontrib><title>Factors Associated with the Prescribing of High-Intensity Statins</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as "high-intensity" or "low-moderate-intensity". Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus <20 METs (metabolic equivalent of task) h/wk; odds ratio (OR), 1.65; 95%CI, 1.08-2.50) and, in diabetics, higher low-density lipoprotein cholesterol (LDL-C) levels (≥155 mg/dL versus <155 mg/dL; OR, 4.96; 95%CI, 1.29-19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574-0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in diabetics with high LDL-C levels and in more physically active individuals. These findings underscore the great variability and uncertainty in the prescribing of statins.</description><subject>Antihypertensives</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Cholesterol</subject><subject>Classification</subject><subject>Clinical medicine</subject><subject>Codes</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Disease prevention</subject><subject>Drug dosages</subject><subject>Lifestyles</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Prescription drugs</subject><subject>Primary care</subject><subject>Questionnaires</subject><subject>Shift work</subject><subject>Sleep</subject><subject>Statins</subject><subject>Workers</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkVtLAzEQhYMoKrUv_gBZ8EWE1SST274IRawKgoL6HNJstpvSbjRJFf-9K631Mi8zMB-HczgIHRJ8BlDh85ldVISC4ngL7VMsZYlBwfavew8NU5rhfpRilMhdtAdABVbA99FobGwOMRWjlIL1Jru6ePe5LXLriofoko1-4rtpEZrixk_b8rbLrks-fxSP2WTfpQO005h5csP1HqDn8dXT5U15d399ezm6Ky3DIpdMEkM4BSIJF5Q7rKSruGWN5YRUjgNlFW0qWYNQTk0wZappLAgJogaOBQzQxUr3ZTlZuNq6Lkcz1y_RL0z80MF4_ffT-VZPw5uWUmCGoRc4WQvE8Lp0KeuFT9bN56ZzYZk0ZULQigole_T4HzoLy9j18TQVjGAhREV66nRF2RhSiq7ZmCFYf5Wjf8rp4aPf9jfodxXwCejdiAU</recordid><startdate>20201127</startdate><enddate>20201127</enddate><creator>Chaure-Pardos, Armando</creator><creator>Malo, Sara</creator><creator>Rabanaque, María José</creator><creator>Arribas, Federico</creator><creator>Moreno-Franco, Belén</creator><creator>Aguilar-Palacio, Isabel</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7293-701X</orcidid><orcidid>https://orcid.org/0000-0002-7194-8275</orcidid><orcidid>https://orcid.org/0000-0002-6671-5661</orcidid></search><sort><creationdate>20201127</creationdate><title>Factors Associated with the Prescribing of High-Intensity Statins</title><author>Chaure-Pardos, Armando ; Malo, Sara ; Rabanaque, María José ; Arribas, Federico ; Moreno-Franco, Belén ; Aguilar-Palacio, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-471a15231715625e087e95c4fc5119e532492f97d368e8b0248ffc36736d35063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antihypertensives</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Cholesterol</topic><topic>Classification</topic><topic>Clinical medicine</topic><topic>Codes</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Disease prevention</topic><topic>Drug dosages</topic><topic>Lifestyles</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Prescription drugs</topic><topic>Primary care</topic><topic>Questionnaires</topic><topic>Shift work</topic><topic>Sleep</topic><topic>Statins</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaure-Pardos, Armando</creatorcontrib><creatorcontrib>Malo, Sara</creatorcontrib><creatorcontrib>Rabanaque, María José</creatorcontrib><creatorcontrib>Arribas, Federico</creatorcontrib><creatorcontrib>Moreno-Franco, Belén</creatorcontrib><creatorcontrib>Aguilar-Palacio, Isabel</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaure-Pardos, Armando</au><au>Malo, Sara</au><au>Rabanaque, María José</au><au>Arribas, Federico</au><au>Moreno-Franco, Belén</au><au>Aguilar-Palacio, Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Associated with the Prescribing of High-Intensity Statins</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2020-11-27</date><risdate>2020</risdate><volume>9</volume><issue>12</issue><spage>3850</spage><pages>3850-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>In this study, we investigated the relationship between sociodemographic, clinical, anthropometric, and lifestyle characteristics and the type of statin prescribed for primary prevention of cardiovascular disease (CVD). We conducted an observational study in workers who began statin treatment. Statin therapy was categorized as "high-intensity" or "low-moderate-intensity". Workers were classified according to the alignment of their statin therapy with the recommended management practices. Logistic regression models were used to evaluate the association between the different variables studied and the probability of being prescribed high-intensity statins. The only variables associated with a higher probability of being treated with high-intensity statins were increased physical activity (>40 versus <20 METs (metabolic equivalent of task) h/wk; odds ratio (OR), 1.65; 95%CI, 1.08-2.50) and, in diabetics, higher low-density lipoprotein cholesterol (LDL-C) levels (≥155 mg/dL versus <155 mg/dL; OR, 4.96; 95%CI, 1.29-19.10). The model that best predicted treatment intensity included LDL-C, diabetes, hypertension, smoking, and age (area under the Receiver Operating Characteristic curve (AUC), 0.620; 95%CI, 0.574-0.666). The prescribing and type of statin used in primary CVD prevention did not correspond with the indications in current guidelines. The probability of receiving high-intensity statins was higher in diabetics with high LDL-C levels and in more physically active individuals. These findings underscore the great variability and uncertainty in the prescribing of statins.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33260835</pmid><doi>10.3390/jcm9123850</doi><orcidid>https://orcid.org/0000-0001-7293-701X</orcidid><orcidid>https://orcid.org/0000-0002-7194-8275</orcidid><orcidid>https://orcid.org/0000-0002-6671-5661</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Antihypertensives Atherosclerosis Blood pressure Cholesterol Classification Clinical medicine Codes Diabetes Diet Disease prevention Drug dosages Lifestyles Lipids Lipoproteins Prescription drugs Primary care Questionnaires Shift work Sleep Statins Workers |
| title | Factors Associated with the Prescribing of High-Intensity Statins |
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