Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature
This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral-brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic se...
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| Veröffentlicht in: | Journal of clinical medicine 2020-11, Vol.9 (12), p.3876, Article 3876 |
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| creator | Maitre, Yoann Micheneau, Pierre Delpierre, Alexis Mahalli, Rachid Guerin, Marie Amador, Gilles Denis, Frederic |
| description | This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral-brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic search through the MEDLINE database, to identify studies that have explored the role of the oral microbiome in the pathophysiology of mental health disorders published from 2000 up to June 2020. The search resulted in 140 records; after exclusions, a total of 22 papers were included in the present review. In accordance with the role of the oral microbiome in the pathophysiology of mental disorders, four mental disorders were identified: Alzheimer's disease, dementia, and cognitive disorders; autism spectrum disorder; Down's syndrome and mental retardation; and Bipolar disorders. Studies argue for correlations between oral microbiota and Alzheimer's disease, autism spectrum disorders, Down's syndrome, and bipolar disorders. This field is still under-studied, and studies are needed to clarify the biological links and interconnections between the oral microbiota and the pathophysiology of all mental health disorders. Researchers should focus their efforts to develop research on the oral-brain axis in the future. |
| doi_str_mv | 10.3390/jcm9123876 |
| format | Article |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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| subjects | Bacteria Biomarkers Brain research Cardiovascular disease Clinical medicine Dental caries General & Internal Medicine Humanities and Social Sciences Immune system Life Sciences Life Sciences & Biomedicine Medicine, General & Internal Mental disorders Mental health care Metabolites Microbiota Microorganisms Mouth Nervous system Oral diseases Pancreatic cancer Pathophysiology Physiology Review Rheumatoid arthritis Science & Technology Systematic review Systemic diseases |
| title | Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature |
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