LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma

Glioblastoma (GBM) is the most common primary brain malignancy in adults, with a 100% recurrence rate and 21-month median survival. Our lab and others have shown that GBM contains a subpopulation of glioma stem cells (GSCs) that expand during chemotherapy and may contribute to therapeutic resistance...

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Veröffentlicht in:	Cancers 2020-11, Vol.12 (12), p.3505
Hauptverfasser:	Baisiwala, Shivani, Hall, 3rd, Robert R, Saathoff, Miranda R, M Shireman, Jack, Park, Cheol, Budhiraja, Shreya, Goel, Chirag, Warnke, Louisa, Hardiman, Clare, Wang, Jennifer Y, McCortney, Katy, Horbinski, Craig M, Ahmed, Atique U
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain tumors Cell cycle Cell division Chemotherapy Datasets Experiments Flow cytometry Gene expression Genotype & phenotype Glioblastoma Glioma cells Intracellular signalling Notch1 protein NUMB protein Patients Stem cell transplantation Stem cells Temozolomide Xenografts
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