Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans

In C. elegans, expression of the UPRER transcription factor xbp-1s in neurons cell non-autonomously activates the UPRER in the intestine, leading to enhanced proteostasis and lifespan. To better understand this signaling pathway, we isolated neurons from animals expressing neuronal xbp-1s for transc...

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Veröffentlicht in:	Developmental cell 2020-12, Vol.55 (6), p.754-770.e6
Hauptverfasser:	Özbey, Neşem P., Imanikia, Soudabeh, Krueger, Christel, Hardege, Iris, Morud, Julia, Sheng, Ming, Schafer, William R., Casanueva, M. Olivia, Taylor, Rebecca C.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging C. elegans ER stress neurobiology proteostasis signaling stress response
Online-Zugang:	Volltext
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