Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro

Community-acquired pneumonia by primary or superinfections with Streptococcus pneumoniae can lead to acute respiratory distress requiring mechanical ventilation. The pore-forming toxin pneumolysin alters the alveolar-capillary barrier and causes extravasation of protein-rich fluid into the interstit...

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Veröffentlicht in:	Blood advances 2020-12, Vol.4 (24), p.6315-6326
Hauptverfasser:	Jahn, Kristin, Handtke, Stefan, Palankar, Raghavendra, Weißmüller, Sabrina, Nouailles, Geraldine, Kohler, Thomas P., Wesche, Jan, Rohde, Manfred, Heinz, Corina, Aschenbrenner, Axel F., Wolff, Martina, Schüttrumpf, Jörg, Witzenrath, Martin, Hammerschmidt, Sven, Greinacher, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins Humans Immunoglobulins Platelet Activation Platelets and Thrombopoiesis Prospective Studies Streptolysins
Online-Zugang:	Volltext
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