Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor

Single chemical entities with potential to simultaneously interact with two binding sites are emerging strategies in medicinal chemistry. We have designed, synthesized and functionally characterized the first bitopic ligands for the CB2 receptor. These compounds selectively target CB2 versus CB1 rec...

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Veröffentlicht in:	Chemistry : a European journal 2020-12, Vol.26 (68), p.15839-15842
Hauptverfasser:	Morales, Paula, Navarro, Gemma, Gómez‐Autet, Marc, Redondo, Laura, Fernández‐Ruiz, Javier, Pérez‐Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites bitopic ligands Cannabinoid CB1 receptors Cannabinoid CB2 receptors CB2 cannabinoid Chemical synthesis Chemistry Communication Communications G protein-coupled receptors Ligands Molecular dynamics Receptors Site-directed mutagenesis
Online-Zugang:	Volltext
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