Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy
Background Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis. Methods The OraRad multicenter prospective cohort study enrolled HNC patients receiving cu...
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| Veröffentlicht in: | Head & neck 2021-01, Vol.43 (1), p.164-172 |
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| creator | Brennan, Michael T. Treister, Nathaniel S. Sollecito, Thomas P. Schmidt, Brian L. Patton, Lauren L. Yang, Yi Lin, Alexander Elting, Linda S. Hodges, James S. Lalla, Rajesh V. |
| description | Background
Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis.
Methods
The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative‐intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics, human papilloma virus (HPV) status, and dental disease measures.
Results
We enrolled 572 participants; 77% male and mean (SD) age of 61.7 (11.2) years. Oropharyngeal squamous cell carcinomas (88% HPV‐related) were seen with smaller tumors, but more frequent nodal involvement. Private medical insurance and no Medicaid were associated with smaller tumors. A higher dental disease burden was associated with larger tumors.
Conclusions
Insurance status, cancer type/location, and dental disease are associated with advanced HNC and may represent potentially modifiable factors or factors to be considered in the screening process of new lesions. |
| doi_str_mv | 10.1002/hed.26468 |
| format | Article |
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Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis.
Methods
The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative‐intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics, human papilloma virus (HPV) status, and dental disease measures.
Results
We enrolled 572 participants; 77% male and mean (SD) age of 61.7 (11.2) years. Oropharyngeal squamous cell carcinomas (88% HPV‐related) were seen with smaller tumors, but more frequent nodal involvement. Private medical insurance and no Medicaid were associated with smaller tumors. A higher dental disease burden was associated with larger tumors.
Conclusions
Insurance status, cancer type/location, and dental disease are associated with advanced HNC and may represent potentially modifiable factors or factors to be considered in the screening process of new lesions.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26468</identifier><identifier>PMID: 32991009</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>baseline features ; Demography ; Dental disorders ; dental health ; Diagnosis ; Epidemiologic Factors ; Epidemiology ; Female ; Head & neck cancer ; head and neck cancer ; Head and Neck Neoplasms - epidemiology ; Head and Neck Neoplasms - radiotherapy ; Human papillomavirus ; Humans ; Male ; Middle Aged ; Original ; Oropharyngolaryngeal carcinoma ; Papillomaviridae ; Prospective Studies ; Radiation therapy ; radiotherapy ; Retrospective Studies ; Squamous cell carcinoma ; Throat cancer ; Tumors</subject><ispartof>Head & neck, 2021-01, Vol.43 (1), p.164-172</ispartof><rights>2020 The Authors. Head & Neck published by Wiley Periodicals LLC.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-93a0e614c43d9c7d3b7898aea5ed0f8270e1fa430b5afe62612c6c7bd85e53923</citedby><cites>FETCH-LOGICAL-c4438-93a0e614c43d9c7d3b7898aea5ed0f8270e1fa430b5afe62612c6c7bd85e53923</cites><orcidid>0000-0003-0638-4335 ; 0000-0002-8253-4588 ; 0000-0002-1471-4026 ; 0000-0002-5596-7222 ; 0000-0003-0569-7743</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26468$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26468$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32991009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brennan, Michael T.</creatorcontrib><creatorcontrib>Treister, Nathaniel S.</creatorcontrib><creatorcontrib>Sollecito, Thomas P.</creatorcontrib><creatorcontrib>Schmidt, Brian L.</creatorcontrib><creatorcontrib>Patton, Lauren L.</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Lin, Alexander</creatorcontrib><creatorcontrib>Elting, Linda S.</creatorcontrib><creatorcontrib>Hodges, James S.</creatorcontrib><creatorcontrib>Lalla, Rajesh V.</creatorcontrib><title>Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis.
Methods
The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative‐intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics, human papilloma virus (HPV) status, and dental disease measures.
Results
We enrolled 572 participants; 77% male and mean (SD) age of 61.7 (11.2) years. Oropharyngeal squamous cell carcinomas (88% HPV‐related) were seen with smaller tumors, but more frequent nodal involvement. Private medical insurance and no Medicaid were associated with smaller tumors. A higher dental disease burden was associated with larger tumors.
Conclusions
Insurance status, cancer type/location, and dental disease are associated with advanced HNC and may represent potentially modifiable factors or factors to be considered in the screening process of new lesions.</description><subject>baseline features</subject><subject>Demography</subject><subject>Dental disorders</subject><subject>dental health</subject><subject>Diagnosis</subject><subject>Epidemiologic Factors</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - epidemiology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Oropharyngolaryngeal carcinoma</subject><subject>Papillomaviridae</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>radiotherapy</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Throat cancer</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1PxCAURYnR-L3wDxgSVy6qFCi0GxMzjh-JiRtdkzfwatGZUmlHM_9exhmNLlxBeOcdbnIJOcrZWc4YP2_QnXElVblBdnNW6YwJqTeXdykywbTcIXt9_8IYE0rybbIjeFWlzWqX2HHnHc58mIZnb2kNdgixp76lHQwe26GnH35oKLh3aC062iA4Cq2jLdpXapePkQ4RYUjDLzSC82k3tHRoMEK3OCBbNUx7PFyf--Tpevw4us3uH27uRpf3mZVSlFklgKHKpZXCVVY7MdFlVQJCgY7VJdcM8xqkYJMCalRc5dwqqyeuLLAQFRf75GLl7eaTGTqb0keYmi76GcSFCeDN30nrG_Mc3o3WhSqUSIKTtSCGtzn2g3kJ89imzIZLpUuxpk5XlI2h7yPWPz_kzCz7MKkP89VHYo9_R_ohvwtIwPkK-PBTXPxvMrfjq5XyE4NhloA</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Brennan, Michael T.</creator><creator>Treister, Nathaniel S.</creator><creator>Sollecito, Thomas P.</creator><creator>Schmidt, Brian L.</creator><creator>Patton, Lauren L.</creator><creator>Yang, Yi</creator><creator>Lin, Alexander</creator><creator>Elting, Linda S.</creator><creator>Hodges, James S.</creator><creator>Lalla, Rajesh V.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0638-4335</orcidid><orcidid>https://orcid.org/0000-0002-8253-4588</orcidid><orcidid>https://orcid.org/0000-0002-1471-4026</orcidid><orcidid>https://orcid.org/0000-0002-5596-7222</orcidid><orcidid>https://orcid.org/0000-0003-0569-7743</orcidid></search><sort><creationdate>202101</creationdate><title>Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy</title><author>Brennan, Michael T. ; Treister, Nathaniel S. ; Sollecito, Thomas P. ; Schmidt, Brian L. ; Patton, Lauren L. ; Yang, Yi ; Lin, Alexander ; Elting, Linda S. ; Hodges, James S. ; Lalla, Rajesh V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-93a0e614c43d9c7d3b7898aea5ed0f8270e1fa430b5afe62612c6c7bd85e53923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>baseline features</topic><topic>Demography</topic><topic>Dental disorders</topic><topic>dental health</topic><topic>Diagnosis</topic><topic>Epidemiologic Factors</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - epidemiology</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Oropharyngolaryngeal carcinoma</topic><topic>Papillomaviridae</topic><topic>Prospective Studies</topic><topic>Radiation therapy</topic><topic>radiotherapy</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Throat cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brennan, Michael T.</creatorcontrib><creatorcontrib>Treister, Nathaniel S.</creatorcontrib><creatorcontrib>Sollecito, Thomas P.</creatorcontrib><creatorcontrib>Schmidt, Brian L.</creatorcontrib><creatorcontrib>Patton, Lauren L.</creatorcontrib><creatorcontrib>Yang, Yi</creatorcontrib><creatorcontrib>Lin, Alexander</creatorcontrib><creatorcontrib>Elting, Linda S.</creatorcontrib><creatorcontrib>Hodges, James S.</creatorcontrib><creatorcontrib>Lalla, Rajesh V.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brennan, Michael T.</au><au>Treister, Nathaniel S.</au><au>Sollecito, Thomas P.</au><au>Schmidt, Brian L.</au><au>Patton, Lauren L.</au><au>Yang, Yi</au><au>Lin, Alexander</au><au>Elting, Linda S.</au><au>Hodges, James S.</au><au>Lalla, Rajesh V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2021-01</date><risdate>2021</risdate><volume>43</volume><issue>1</issue><spage>164</spage><epage>172</epage><pages>164-172</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Approximately 50% of patients with head and neck cancer (HNC) initially were seen with advanced disease. We aimed to evaluate the association of epidemiologic factors with advanced HNC at diagnosis.
Methods
The OraRad multicenter prospective cohort study enrolled HNC patients receiving curative‐intent radiation therapy. Factors assessed for association with advanced HNC presentation at diagnosis included demographics, social and medical history, cancer characteristics, human papilloma virus (HPV) status, and dental disease measures.
Results
We enrolled 572 participants; 77% male and mean (SD) age of 61.7 (11.2) years. Oropharyngeal squamous cell carcinomas (88% HPV‐related) were seen with smaller tumors, but more frequent nodal involvement. Private medical insurance and no Medicaid were associated with smaller tumors. A higher dental disease burden was associated with larger tumors.
Conclusions
Insurance status, cancer type/location, and dental disease are associated with advanced HNC and may represent potentially modifiable factors or factors to be considered in the screening process of new lesions.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32991009</pmid><doi>10.1002/hed.26468</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0638-4335</orcidid><orcidid>https://orcid.org/0000-0002-8253-4588</orcidid><orcidid>https://orcid.org/0000-0002-1471-4026</orcidid><orcidid>https://orcid.org/0000-0002-5596-7222</orcidid><orcidid>https://orcid.org/0000-0003-0569-7743</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | baseline features Demography Dental disorders dental health Diagnosis Epidemiologic Factors Epidemiology Female Head & neck cancer head and neck cancer Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - radiotherapy Human papillomavirus Humans Male Middle Aged Original Oropharyngolaryngeal carcinoma Papillomaviridae Prospective Studies Radiation therapy radiotherapy Retrospective Studies Squamous cell carcinoma Throat cancer Tumors |
| title | Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy |
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