Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic

IMPORTANCE: It is unknown how much the mortality of patients with coronavirus disease 2019 (COVID-19) depends on the hospital that cares for them, and whether COVID-19 hospital mortality rates are improving. OBJECTIVE: To identify variation in COVID-19 mortality rates and how those rates have change...

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Veröffentlicht in:Archives of internal medicine (1960) 2021-04, Vol.181 (4), p.471-478
Hauptverfasser: Asch, David A, Sheils, Natalie E, Islam, Md Nazmul, Chen, Yong, Werner, Rachel M, Buresh, John, Doshi, Jalpa A
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container_end_page 478
container_issue 4
container_start_page 471
container_title Archives of internal medicine (1960)
container_volume 181
creator Asch, David A
Sheils, Natalie E
Islam, Md Nazmul
Chen, Yong
Werner, Rachel M
Buresh, John
Doshi, Jalpa A
description IMPORTANCE: It is unknown how much the mortality of patients with coronavirus disease 2019 (COVID-19) depends on the hospital that cares for them, and whether COVID-19 hospital mortality rates are improving. OBJECTIVE: To identify variation in COVID-19 mortality rates and how those rates have changed over the first months of the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed 38 517 adults who were admitted with COVID-19 to 955 US hospitals from January 1, 2020, to June 30, 2020, and a subset of 27 801 adults (72.2%) who were admitted to 398 of these hospitals that treated at least 10 patients with COVID-19 during 2 periods (January 1 to April 30, 2020, and May 1 to June 30, 2020). EXPOSURES: Hospital characteristics, including size, the number of intensive care unit beds, academic and profit status, hospital setting, and regional characteristics, including COVID-19 case burden. MAIN OUTCOMES AND MEASURES: The primary outcome was the hospital’s risk-standardized event rate (RSER) of 30-day in-hospital mortality or referral to hospice adjusted for patient-level characteristics, including demographic data, comorbidities, community or nursing facility admission source, and time since January 1, 2020. We examined whether hospital characteristics were associated with RSERs or their change over time. RESULTS: The mean (SD) age among participants (18 888 men [49.0%]) was 70.2 (15.5) years. The mean (SD) hospital-level RSER for the 955 hospitals was 11.8% (2.5%). The mean RSER in the worst-performing quintile of hospitals was 15.65% compared with 9.06% in the best-performing quintile (absolute difference, 6.59 percentage points; 95% CI, 6.38%-6.80%; P 
doi_str_mv 10.1001/jamainternmed.2020.8193
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OBJECTIVE: To identify variation in COVID-19 mortality rates and how those rates have changed over the first months of the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed 38 517 adults who were admitted with COVID-19 to 955 US hospitals from January 1, 2020, to June 30, 2020, and a subset of 27 801 adults (72.2%) who were admitted to 398 of these hospitals that treated at least 10 patients with COVID-19 during 2 periods (January 1 to April 30, 2020, and May 1 to June 30, 2020). EXPOSURES: Hospital characteristics, including size, the number of intensive care unit beds, academic and profit status, hospital setting, and regional characteristics, including COVID-19 case burden. MAIN OUTCOMES AND MEASURES: The primary outcome was the hospital’s risk-standardized event rate (RSER) of 30-day in-hospital mortality or referral to hospice adjusted for patient-level characteristics, including demographic data, comorbidities, community or nursing facility admission source, and time since January 1, 2020. We examined whether hospital characteristics were associated with RSERs or their change over time. RESULTS: The mean (SD) age among participants (18 888 men [49.0%]) was 70.2 (15.5) years. The mean (SD) hospital-level RSER for the 955 hospitals was 11.8% (2.5%). The mean RSER in the worst-performing quintile of hospitals was 15.65% compared with 9.06% in the best-performing quintile (absolute difference, 6.59 percentage points; 95% CI, 6.38%-6.80%; P &lt; .001). Mean RSERs in all but 1 of the 398 hospitals improved; 376 (94%) improved by at least 25%. The overall mean (SD) RSER declined from 16.6% (4.0%) to 9.3% (2.1%). The absolute difference in rates of mortality or referral to hospice between the worst- and best-performing quintiles of hospitals decreased from 10.54 percentage points (95% CI, 10.03%-11.05%; P &lt; .001) to 5.59 percentage points (95% CI, 5.33%-5.86%; P &lt; .001). Higher county-level COVID-19 case rates were associated with worse RSERs, and case rate declines were associated with improvement in RSERs. CONCLUSIONS AND RELEVANCE: Over the first months of the pandemic, COVID-19 mortality rates in this cohort of US hospitals declined. Hospitals did better when the prevalence of COVID-19 in their surrounding communities was lower.</description><identifier>ISSN: 2168-6106</identifier><identifier>EISSN: 2168-6114</identifier><identifier>DOI: 10.1001/jamainternmed.2020.8193</identifier><identifier>PMID: 33351068</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cohort Studies ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - mortality ; COVID-19 - therapy ; Critical Care ; Female ; Hospital Mortality ; Hospitalization - statistics &amp; numerical data ; Hospitals ; Humans ; Intensive care ; Male ; Middle Aged ; Mortality ; Online First ; Original Investigation ; Pandemics ; Studies ; United States ; Young Adult</subject><ispartof>Archives of internal medicine (1960), 2021-04, Vol.181 (4), p.471-478</ispartof><rights>Copyright American Medical Association Apr 2021</rights><rights>Copyright 2020 Asch DA et al. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a464t-a1f486158b2e01e1180eab45a44d089f23ababeba8717ca2d9692dff4546cdd3</citedby><cites>FETCH-LOGICAL-a464t-a1f486158b2e01e1180eab45a44d089f23ababeba8717ca2d9692dff4546cdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/articlepdf/10.1001/jamainternmed.2020.8193$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2020.8193$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,230,314,780,784,885,3340,27924,27925,76489,76492</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33351068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asch, David A</creatorcontrib><creatorcontrib>Sheils, Natalie E</creatorcontrib><creatorcontrib>Islam, Md Nazmul</creatorcontrib><creatorcontrib>Chen, Yong</creatorcontrib><creatorcontrib>Werner, Rachel M</creatorcontrib><creatorcontrib>Buresh, John</creatorcontrib><creatorcontrib>Doshi, Jalpa A</creatorcontrib><title>Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic</title><title>Archives of internal medicine (1960)</title><addtitle>JAMA Intern Med</addtitle><description>IMPORTANCE: It is unknown how much the mortality of patients with coronavirus disease 2019 (COVID-19) depends on the hospital that cares for them, and whether COVID-19 hospital mortality rates are improving. OBJECTIVE: To identify variation in COVID-19 mortality rates and how those rates have changed over the first months of the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed 38 517 adults who were admitted with COVID-19 to 955 US hospitals from January 1, 2020, to June 30, 2020, and a subset of 27 801 adults (72.2%) who were admitted to 398 of these hospitals that treated at least 10 patients with COVID-19 during 2 periods (January 1 to April 30, 2020, and May 1 to June 30, 2020). EXPOSURES: Hospital characteristics, including size, the number of intensive care unit beds, academic and profit status, hospital setting, and regional characteristics, including COVID-19 case burden. MAIN OUTCOMES AND MEASURES: The primary outcome was the hospital’s risk-standardized event rate (RSER) of 30-day in-hospital mortality or referral to hospice adjusted for patient-level characteristics, including demographic data, comorbidities, community or nursing facility admission source, and time since January 1, 2020. We examined whether hospital characteristics were associated with RSERs or their change over time. RESULTS: The mean (SD) age among participants (18 888 men [49.0%]) was 70.2 (15.5) years. The mean (SD) hospital-level RSER for the 955 hospitals was 11.8% (2.5%). The mean RSER in the worst-performing quintile of hospitals was 15.65% compared with 9.06% in the best-performing quintile (absolute difference, 6.59 percentage points; 95% CI, 6.38%-6.80%; P &lt; .001). Mean RSERs in all but 1 of the 398 hospitals improved; 376 (94%) improved by at least 25%. The overall mean (SD) RSER declined from 16.6% (4.0%) to 9.3% (2.1%). The absolute difference in rates of mortality or referral to hospice between the worst- and best-performing quintiles of hospitals decreased from 10.54 percentage points (95% CI, 10.03%-11.05%; P &lt; .001) to 5.59 percentage points (95% CI, 5.33%-5.86%; P &lt; .001). Higher county-level COVID-19 case rates were associated with worse RSERs, and case rate declines were associated with improvement in RSERs. CONCLUSIONS AND RELEVANCE: Over the first months of the pandemic, COVID-19 mortality rates in this cohort of US hospitals declined. Hospitals did better when the prevalence of COVID-19 in their surrounding communities was lower.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cohort Studies</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - mortality</subject><subject>COVID-19 - therapy</subject><subject>Critical Care</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Hospitalization - statistics &amp; numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intensive care</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Online First</subject><subject>Original Investigation</subject><subject>Pandemics</subject><subject>Studies</subject><subject>United States</subject><subject>Young Adult</subject><issn>2168-6106</issn><issn>2168-6114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxSMEolXpF-AAlrhwyeJ_sZ0LUrWltFJRKyjlaE1ip-tVYm9tp1K_PV62rCi-jOX5zdMbv6p6T_CCYEw-rWEC57ONfrJmQTHFC0Va9qI6pESoWhDCX-7vWBxUxymtcTkKY87Y6-qAMdaUjjqsHm4hOsgueOQ8-vkDnYe0cRlG9C3EUlx-RN8h24SGENF1Ia3PCZ2YyeVsDfrl8gotr24vTmvSotM5On-H8sqiMxdTRqLI-LxKKAx_Xq_BGzu5_k31aoAx2eOnelTdnH25WZ7Xl1dfL5YnlzVwwXMNZOBKkEZ11GJiCVHYQscb4Nxg1Q6UQQed7UBJInugphUtNcPAGy56Y9hR9Xknu5m78ld98R5h1JvoJoiPOoDTzzverfRdeNBSNoJyUQQ-PgnEcD_blPXkUm_HEbwNc9KUS0qKrZYU9MN_6DrM0ZftNG0o5VRiQQsld1QfQ0rRDnszBOttuvpZunqbrt6mWybf_bvLfu5vlgV4uwOKwL5LpeSNpOw3RaatLg</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Asch, David A</creator><creator>Sheils, Natalie E</creator><creator>Islam, Md Nazmul</creator><creator>Chen, Yong</creator><creator>Werner, Rachel M</creator><creator>Buresh, John</creator><creator>Doshi, Jalpa A</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210401</creationdate><title>Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic</title><author>Asch, David A ; 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of internal medicine (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asch, David A</au><au>Sheils, Natalie E</au><au>Islam, Md Nazmul</au><au>Chen, Yong</au><au>Werner, Rachel M</au><au>Buresh, John</au><au>Doshi, Jalpa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic</atitle><jtitle>Archives of internal medicine (1960)</jtitle><addtitle>JAMA Intern Med</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>181</volume><issue>4</issue><spage>471</spage><epage>478</epage><pages>471-478</pages><issn>2168-6106</issn><eissn>2168-6114</eissn><abstract>IMPORTANCE: It is unknown how much the mortality of patients with coronavirus disease 2019 (COVID-19) depends on the hospital that cares for them, and whether COVID-19 hospital mortality rates are improving. OBJECTIVE: To identify variation in COVID-19 mortality rates and how those rates have changed over the first months of the pandemic. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed 38 517 adults who were admitted with COVID-19 to 955 US hospitals from January 1, 2020, to June 30, 2020, and a subset of 27 801 adults (72.2%) who were admitted to 398 of these hospitals that treated at least 10 patients with COVID-19 during 2 periods (January 1 to April 30, 2020, and May 1 to June 30, 2020). EXPOSURES: Hospital characteristics, including size, the number of intensive care unit beds, academic and profit status, hospital setting, and regional characteristics, including COVID-19 case burden. MAIN OUTCOMES AND MEASURES: The primary outcome was the hospital’s risk-standardized event rate (RSER) of 30-day in-hospital mortality or referral to hospice adjusted for patient-level characteristics, including demographic data, comorbidities, community or nursing facility admission source, and time since January 1, 2020. We examined whether hospital characteristics were associated with RSERs or their change over time. RESULTS: The mean (SD) age among participants (18 888 men [49.0%]) was 70.2 (15.5) years. The mean (SD) hospital-level RSER for the 955 hospitals was 11.8% (2.5%). The mean RSER in the worst-performing quintile of hospitals was 15.65% compared with 9.06% in the best-performing quintile (absolute difference, 6.59 percentage points; 95% CI, 6.38%-6.80%; P &lt; .001). Mean RSERs in all but 1 of the 398 hospitals improved; 376 (94%) improved by at least 25%. The overall mean (SD) RSER declined from 16.6% (4.0%) to 9.3% (2.1%). The absolute difference in rates of mortality or referral to hospice between the worst- and best-performing quintiles of hospitals decreased from 10.54 percentage points (95% CI, 10.03%-11.05%; P &lt; .001) to 5.59 percentage points (95% CI, 5.33%-5.86%; P &lt; .001). Higher county-level COVID-19 case rates were associated with worse RSERs, and case rate declines were associated with improvement in RSERs. CONCLUSIONS AND RELEVANCE: Over the first months of the pandemic, COVID-19 mortality rates in this cohort of US hospitals declined. Hospitals did better when the prevalence of COVID-19 in their surrounding communities was lower.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>33351068</pmid><doi>10.1001/jamainternmed.2020.8193</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Cohort Studies
COVID-19
COVID-19 - diagnosis
COVID-19 - mortality
COVID-19 - therapy
Critical Care
Female
Hospital Mortality
Hospitalization - statistics & numerical data
Hospitals
Humans
Intensive care
Male
Middle Aged
Mortality
Online First
Original Investigation
Pandemics
Studies
United States
Young Adult
title Variation in US Hospital Mortality Rates for Patients Admitted With COVID-19 During the First 6 Months of the Pandemic
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