A novel treatment for skin repair using a combination of spironolactone and vitamin D3

Injury of the skin from exposure to toxic chemicals leads to the release of inflammatory mediators and the recruitment of immune cells. Nitrogen mustard (NM) and other alkylating agents cause severe cutaneous damage for which there are limited treatment options. Here, we show that combined treatment...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2020-11, Vol.1480 (1), p.170-182
Hauptverfasser:	Biyashev, Dauren, Onay, Ummiye V., Dalal, Prarthana, Demczuk, Michael, Evans, Spencer, Techner, José‐Marc, Lu, Kurt Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating agents Alkylation Animals Apoptosis Apoptosis - drug effects Chemokines Cholecalciferol - pharmacology Combined treatment Exposure Female Gene Expression Regulation - drug effects Immune response Immune system Inflammation Interleukins Macrophages Macrophages - metabolism Macrophages - pathology Matrix metalloproteinases Mechlorethamine - toxicity Metalloproteinase Mice Mustard Nitric-oxide synthase nitrogen mustard Original RAW 264.7 Cells Repair Skin Skin - injuries Skin - metabolism Skin - pathology skin injury spironolactone Spironolactone - pharmacology vitamin D Vitamin D3 Wound healing Wound Healing - drug effects Wounds and Injuries - chemically induced Wounds and Injuries - drug therapy Wounds and Injuries - metabolism Wounds and Injuries - pathology
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