gB co‐immunization with GP96 enhances pulmonary‐resident CD8 T cells and exerts a long‐term defence against MCMV pneumonitis

Human cytomegalovirus (HCMV) infection in the respiratory tract leads to pneumonitis in immunocompromised hosts without available vaccine. Considering cytomegalovirus (CMV) mainly invades through the respiratory tract, CMV‐specific pulmonary mucosal vaccine development that provides a long‐lasting p...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-12, Vol.24 (24), p.14426-14440
Hauptverfasser:	Guo, Bingnan, Xu, Peifeng, Chai, Dafei, Cao, Lei, Liu, Lin, Song, Tengfei, Hu, Shuqun, Chen, Yuling, Yan, Xianliang, Xu, Tie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Administration, Intranasal Animals CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Deoxyribonucleic acid Disease Models, Animal DNA DNA vaccine Female Gene expression Glycoprotein B Glycoprotein gp96 GP96 Host-Pathogen Interactions Humans Immunization Immunocompromised hosts Immunologic Memory Infections Laboratory animals Lung - immunology Lung - pathology Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Medical research Mice Mucosa Original Pathogens Plasmids Plasmids - genetics Pneumonia - immunology Pneumonia - virology Pneumonitis pulmonary‐resident CD8 T cell Respiration Respiratory tract diseases Spleen Spleen - immunology Spleen - pathology Vaccination Vaccine development Vaccines Vaccines, DNA - immunology Viral Proteins - immunology Viral Vaccines - immunology Virulence
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