P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection

CD4+T cells differentiate into distinct functional effector and inhibitory subsets are facilitated by distinct cytokine cues present at the time of antigen recognition. Maintaining a balance between T helper 17 (Th17) and regulatory T (Treg) cells are critical for the control of the immunopathogenes...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2020-12, Vol.24 (24), p.14325-14338
Hauptverfasser:	Chang, Hao, He, Kai‐Yue, Li, Chen, Ni, Yang‐Yue, Li, Mai‐Ning, Chen, Lin, Hou, Min, Zhou, Zikai, Xu, Zhi‐Peng, Ji, Min‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Alzheimer's disease Animals Antigens Antigens, Helminth - immunology Biomarkers CD4 antigen Cell activation Cell differentiation Cells Cytokines - metabolism Cytoskeleton Disease Models, Animal Effector cells Eggs Flow cytometry Gene expression Helminthiasis - metabolism Helminthiasis - parasitology Helper cells Hepatocytes IL‐6 Immunomodulation Immunopathogenesis Immunophenotyping Infections Interferon regulatory factor 1 Kinases Life sciences Liver Liver diseases Lymphocytes Lymphocytes T macrophage Macrophages Macrophages - immunology Macrophages - metabolism Medical research Mice mRNA Nuclear transport Original P21 Activated Kinase‐1 p21-activated kinase p21-Activated Kinases - metabolism Parasitic diseases Pathogens Schistosomiasis japonica - immunology Schistosomiasis japonica - metabolism Schistosomiasis japonica - parasitology Spleen T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th17 cell Th17 Cells - immunology Th17 Cells - metabolism Treg cell
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