High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort

Background/Objectives Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. The placenta has been implicated in how maternal hyperglycaemia generates fetal pathophysiology, but no studies have examined whether placental i...

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Veröffentlicht in:	International Journal of Obesity 2021-01, Vol.45 (1), p.247-257
Hauptverfasser:	Chu, Anne H. Y., Tint, Mya T., Chang, Hsin F., Wong, Gerard, Yuan, Wen Lun, Tull, Dedreia, Nijagal, Brunda, Narayana, Vinod K., Meikle, Peter J., Chang, Kenneth T. E., Lewis, Rohan M., Chi, Claudia, Yap, Fabian K. P., Tan, Kok Hian, Shek, Lynette P., Chong, Yap-Seng, Gluckman, Peter D., Lee, Yung Seng, Fortier, Marielle V., Godfrey, Keith M., Eriksson, Johan G., Karnani, Neerja, Chan, Shiao-Yng
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163/2743 692/700/2814 82/58 Adipose tissue Adiposity - physiology Adult Birth weight Birth Weight - physiology Blood glucose Blood Glucose - analysis Blood sugar Diabetes mellitus Diabetes, Gestational - epidemiology Dietary supplements Epidemiology Female Fetal macrosomia Fetuses Gestation Glucose Glucose tolerance Health aspects Health Promotion and Disease Prevention Humans Hyperglycemia Infant, Newborn Inositol Inositol - analysis Insulin Internal Medicine Liquid chromatography Longitudinal Studies Magnetic resonance imaging Male Mass spectrometry Mass spectroscopy Medicine Medicine & Public Health Metabolic Diseases Neonates Offspring Physiological aspects Placenta Placenta - chemistry Pregnancy Pregnant women Prenatal experience Prenatal influences Prevention Public Health Regression analysis Risk factors Tobacco Vagina Young Adult
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