Origin and Evolution of Fusidane-Type Antibiotics Biosynthetic Pathway through Multiple Horizontal Gene Transfers

Abstract Fusidane-type antibiotics represented by fusidic acid, helvolic acid, and cephalosporin P1 have very similar core structures, but they are produced by fungi belonging to different taxonomic groups. The origin and evolution of fusidane-type antibiotics biosynthetic gene clusters (BGCs) in di...

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Veröffentlicht in:	Genome biology and evolution 2020-10, Vol.12 (10), p.1830-1840
Hauptverfasser:	Li, Xiangchen, Cheng, Jian, Liu, Xiaonan, Guo, Xiaoxian, Liu, Yuqian, Fan, Wenjing, Lu, Lina, Ma, Yanhe, Liu, Tao, Tao, Shiheng, Jiang, Huifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - biosynthesis Biological Evolution Biosynthetic Pathways Cytochrome P-450 Enzyme System - genetics Fungi - genetics Fusidic Acid - metabolism Gene Transfer, Horizontal Genome, Fungal Intramolecular Transferases - genetics Multigene Family
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