CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish

The transcription factor Nrf2a induces a cellular antioxidant response and provides protection against chemical-induced oxidative stress, as well as playing a critical role in development and disease. Zebrafish are a powerful model to study the role of Nrf2a in these processes but have been limited...

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Veröffentlicht in:	Chemical research in toxicology 2020-02, Vol.33 (2), p.426-435
Hauptverfasser:	Mills, Margaret G, Ramsden, Richard, Ma, Eva Y, Corrales, Jone, Kristofco, Lauren A, Steele, W. Baylor, Saari, Gavin N, Melnikov, Fjodor, Kostal, Jakub, Kavanagh, Terrance J, Zimmerman, Julie B, Voutchkova-Kostal, Adelina M, Brooks, Bryan W, Coish, Philip, Anastas, Paul T, Gallagher, Evan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzene Derivatives - toxicity Clustered Regularly Interspaced Short Palindromic Repeats - drug effects Clustered Regularly Interspaced Short Palindromic Repeats - genetics Dose-Response Relationship, Drug Gain of Function Mutation - drug effects Loss of Function Mutation - drug effects NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress - drug effects Oxidative Stress - genetics tert-Butylhydroperoxide - toxicity Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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